Outsourced Pharma App Notes & Case Studies

  1. Improvements In Recovery, Reproducibility, And Matrix Effects With A Novel Solid Phase Extraction Sorbent 6/30/2022

    In this study we review a successful next generation reversed  solid-phase extraction (SPE) product that produces cleaner extracts with simpler protocols and faster processing time.

  2. Manufacturing Expenditure By Activity 7/6/2021

    Learn about the competitive activities that clinical manufacturing sponsors spend the most money on, while gaining some insight into the clinical manufacturing market and where it’s heading.

     
  3. Capture Of Histidine-Tagged Molecules Using Biacore His Capture Kit 10/21/2021

    Find recommendations for immobilization of histidine-tagged molecules (ligands) by capture to an anti-histidine antibody covalently coupled to a sensor chip surface.

  4. Learn How Compliance-Ready LC-MS Workflows for Oligonucleotides Can Expand your Analytical Services Portfolio 2/22/2022

    CMO invests in solution to ensure data integrity and meet regulatory requirements as they expand their oligonucleotide manufacturing and analysis services.

  5. Fixed Dose Combination Drugs 1/19/2022

    A company was seeking a CDMO partner with the expertise and technological capabilities to combine three drug substances into a fixed dose combination product suitable for adult and pediatric dosing.

  6. Capture Of Bispecific Antibodies And Removal Of Product-Related Impurities 11/17/2022

    Many antibody variants are prone to aggregation or to forming product-related impurities. Explore the application of a resin with novel selectivity to purify challenging entities.

  7. N-Linked Glycan Analysis For Complex Glycoproteins 12/20/2021

    An established cell line and a bench-scale manufacturing process for a complex glycoprotein produced high quality material but had a low yield and was not scalable.

  8. Performance Stability Of CORTECS 2.7 μm Columns Following Repeated Injections Of Precipitated Plasma 7/1/2022

    We review a column made using optimally packed solid-core particles. These columns are designed to tolerate repeated injections of minimally processed samples, while maintaining assay performance.

  9. Delivering A Large-Scale Product At A Rapid Pace 8/24/2022

    A pharmaceutical client needed to introduce, manufacture, and validate five stages of challenging chemistry to support a Phase III clinical development program.

  10. SELECT SERIES Cyclic IMS System 11/17/2022

    Explore the utility of Electron Capture Dissociation (ECD) on the SELECT SERIES Cyclic IMS instrument for unambiguous assignment of glycosylation site locations for 11 Oglycopeptide species of ENBREL (etanercept).