Outsourced Pharma App Notes & Case Studies

  1. Medium Preparation For Single-Use Fermentation
    11/17/2017

    To overcome many of the challenges associated with stainless steel vessels, single‑use fermentors offer an increasingly viable alternative. 

  2. Risk Mitigation For Material Transport: The Impact Of Re-Using Shippers
    3/7/2019

    Ensuring your material is stored under appropriate conditions is only half the battle in preserving its integrity. Equally as critical is the precarious process of transporting your material to its destination, safely and in the same condition it was sent in. Maintaining the chain of custody is of utmost importance, and a large component of this is based on the vessel selected for transportation. In this article, we’ll share some key items to consider when selecting shippers to transport your high value material.

  3. Controlling Complexity (Not Cost) Of Advanced Therapy Supply Chains
    4/10/2019

    Due to the short shelf life and clinical criticality of advanced therapies, their supply chains are often highly complex.  Once efficacy and safety is demonstrated, the focus of advanced therapy developers moves to controlling cost.  However, the biggest cost within the supply chain is caused by its complexity.  In this article, we will share why the advanced therapy supply chain is so complex and how this complexity correlates to cost.

  4. Adenovirus Production In Single-Use Xcellerex™ XDR-10 Bioreactor System
    9/10/2018

    This application note describes the production of adenovirus in HEK293 cells cultured in HyClone™ CDM4HEK293 culture medium.

  5. Optimization Of Midstream Cell Lysis And Virus Filtration Steps In An Adenovirus Purification Process
    9/10/2018

    Here we describe screening of detergents for release of adenovirus from HEK293 host cells to replace the traditionally used detergent Triton™.

  6. Innovative Clinical Supply Solutions - Cold Chain
    6/11/2019

    With our team of packaging experts and extensive cold chain capabilities, this case study discusses the creation of a custom packaging and distribution solution to meet this client’s unique needs. Through our partnership, the product was successfully packaged in sufficient quantity and on time for the Phase I trial.

  7. End-To-End Process For Oncolytic Adenovirus Production
    3/20/2019

    Oncolytic viruses constitute a new promising therapeutic approach for treatment of cancer. Here’s an example of a scalable, end-to-end process for oncolytic adenovirus production using modern tools and technologies.

  8. Use Of Sodium Hydroxide For Cleaning And Sanitization Of Chromatography Resins And Systems
    10/2/2018

    This application note examines these aspects of using sodium hydroxide as a cleaning and sanitizing agent.

  9. Are You Ready For The Future of Biomanufacturing?
    1/19/2018

    As novel medicines become a larger part of the industry's portfolio, it is critical you secure a supply chain and manufacturing processes that produce drugs in a reliable, cost-effective way. 

  10. Partnering With Your Teams To Enhance And Increase Supply Chain Efficiency
    4/10/2018

    Emerging biopharmaceutical company teams up with clinical services company to stay on track with timelines and ensure funding milestones were met when faced with unexpected lack of bandwidth and limited global organizational experience.