Outsourced Pharma App Notes & Case Studies

1. A Transient Cell Line To Produce rAAV With Low-Level hcDNA Encapsidation 1/15/2025

   Discover the ability of a novel HEK293 suspension cell line for efficient and scalable rAAV production across various serotypes with low encapsidated host cell DNA levels.

2. Accelerate LNP Manufacturing With Automated Process Development 2/5/2026

   Manual LNP formulation introduces process variability that threatens particle quality and yield. As programs scale toward clinical production, maintaining strict control over CQAs becomes essential.

3. Impact Of Media Selection 6/30/2025

   To highlight the importance of media selection, a study was conducted assessing the effect of three commercially available cGMP grade medias and their influence on T-cell phenotype.

4. Microbial Recovery And Flow Performance With Membranes 2/25/2026

   Compare membrane materials and pore sizes to assess their impact on flow rate and microbial recovery. See how fast filtration and ≥90% organism recovery offer guidance for selecting reliable membranes.

5. Advanced Sequencing Approaches For Comprehensive AAV Vector Characterization 10/28/2025

   Short and long read sequencing offer complementary insights into AAV vector identity, integrity, and impurity profiles, helping developers improve safety, efficacy, and scalability of gene therapy products.

6. CDMO Uses Robotic Gloveless Isolator For Advanced Therapeutics 4/28/2025

   CDMOs must innovate production architectures to meet the demands of advanced therapeutics to ensure a reliable supply and compliance. Discover how these approaches advance modern medicine and improve patient outcomes.

7. Fab-Oligo Conjugation 8/25/2025

   Explore a platform process towards the production of Fab-siRNA conjugates that proves to be scalable and efficient. Find out more about how bioconjugation services can improve your discovery program.

8. Meeting Annex 1: A Proactive Approach To Regulatory Compliance 3/4/2025

   It was imperative for a large European CMO producing multiple biologics to select the right product quality and value for each customer to comply with the August 2023 EU GMP Annex 1 revision.

9. Overcoming The Solubility Challenges Of Antibody-Drug Conjugates 6/3/2024

   Discover a chito-oligosaccharide that significantly improves the solubility of antibody-drug conjugates (ADCs) when included in the linker-payload construct.

10. Media And Buffer Mixing Using The Xcellerex™ Magnetic Mixer 6/19/2024

    A common requirement for media and buffer preparation in biopharma processing is powder-liquid mixing. Review the performance of a 3000 L single-use mixing system for preparing aqueous solutions.