Outsourced Pharma App Notes & Case Studies

1. Development Of A Novel Cell Culture Medium For AAV Production 9/26/2023

   Explore the medium development process of a novel cell culture medium for AAV production with multiple HEK293 lineages, which was performed with three different HEK293 cell lines to maximize AAV titers.

2. Production Of A Highly Concentrated Monoclonal Antibody 10/4/2024

   The production of a highly concentrated monoclonal antibody requires many process steps. Discover how to achieve a final mAb concentration above 200 g/L while maintaining critical quality attributes.

3. Formulation Development For Therapeutic Oligonucleotides 6/10/2025

   Discover how expert formulation and analytical support enable the development of stable, injectable oligonucleotide therapies across diverse delivery routes and molecule types.

4. Raman As A Quality Control Tool For Cell Culture Media Preparation 6/14/2024

   Explore study results demonstrating how Raman technology easily differentiates between media with similar compositions and detects potential preparation errors that other analysis methods might miss.

5. Integrating Phase-Appropriate Quality Standards 12/9/2024

   Incorporating phase-specific quality standards ensures GMP compliance. Collaborating with an experienced CDMO addresses late-stage quality needs and efficiently manages development timelines.

6. Accelerating The Development And Optimization Of Cell Culture Media 10/18/2024

   Here, we outline the use of a microbioreactor for the rapid screening and optimization of media formulations for perfusion processes, and its role in predicting the performance of larger-scale bioreactors.

7. Development Strategies For Adenovirus-Based Gene Therapies 11/11/2024

   Scaling up viral vector production can be challenging, and ensuring consistent titers and activity requires careful optimization and technical expertise.

8. Media And Buffer Mixing Using The Xcellerex™ Magnetic Mixer 6/19/2024

   A common requirement for media and buffer preparation in biopharma processing is powder-liquid mixing. Review the performance of a 3000 L single-use mixing system for preparing aqueous solutions.

9. Engineering The Future Of Lipsomal Drug Delivery 5/14/2025

   Explore our full collection of case studies to discover how liposome technology is transforming drug delivery across a wide range of therapies.

10. Introducing SUPR 3/28/2025

    Validating the performance of Getinge 50L and 250L single-use bioreactors alongside smaller-scale systems can optimize production processes and ensure scalability for CHO cell cultivation.