Small Molecule API CMO Partners
The FDA defines Active Pharmaceutical Ingredient (API) as any substance or mixture of substances intended to be used as the active ingredient in the manufacture of a drug or medicinal product.
Your API may need to be in the form of liquids, powders, crystals and extracts, and processed by chemical synthesis, plant extraction, or other means. The synthesis of small-molecule APIs, although successfully performed for decades, still presents a complicated, multi-step process involving chemical transformations and operations on a range of raw materials with different physical and chemical properties. Specialized expertise is needed to achieve success, from small-scale development, to cGMP clinical and commercial quantities.
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Small Molecule API CMOs
Abbvie
AbbVie Contract Manufacturing partners with companies across the globe to develop, scale and manufacture pharmaceutical products and bring them successfully to market. Drawing on more than four decades of success as the manufacturing division of AbbVie, we have the depth of experience and the technical knowledge to navigate issues and deliver the innovative solutions customers need. We are much more than a CMO – we are your partner for success.
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Almac Pharma Services
With 55+ years’ experience, Almac Pharma Services is a trusted global CDMO providing integrated pharmaceutical development, clinical and commercial manufacturing, packaging, product launch and supply chain solutions. Our highly skilled teams in facilities across the UK, Europe and the US, support over 65 pharmaceutical and biotechnology companies from early-phase development to commercial supply, delivering tailored solutions backed by technical expertise, quality excellence and world-class project management.
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Cambrex
Cambrex is a leading global CDMO that provides drug substance, drug product, and analytical services across the entire drug lifecycle. With over 40 years of experience and a growing team of over 2,200 experts servicing global clients from North America and European sites, Cambrex is a trusted partner in branded and generic markets for API and dosage form development and manufacturing.
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Catalent
Catalent is a global leader in providing integrated services, superior drug delivery technologies and manufacturing solutions to help life science innovators develop and launch successful pharmaceuticals, biologics and consumer health products.
Curia
Curia is a Contract Development and Manufacturing Organization with over 30 years of experience, an integrated network of 27 global sites, and over 3,500 employees partnering with customers to make treatments broadly accessible to patients. Our biologics and small molecule offering spans discovery through commercialization, with integrated regulatory and analytical capabilities.
Flamma
Flamma is an award-winning, family-owned and run CDMO with more than 75 years of expertise in small‑molecule development and cGMP manufacturing. Headquartered near Milan, Italy, Flamma operates five integrated sites across Italy, the USA, and China, delivering a secure and reliable global supply chain. Specializing in small‑molecule APIs, NCEs, RSMs, and advanced intermediates, Flamma is also recognized for its capabilities in high‑value amino acid derivatives and small peptides. Supporting programs from early pre‑clinical grams through commercial metric‑ton scale, Flamma partners with biotech and pharmaceutical companies worldwide using Chemistry With a Human Touch and delivering CDMO Excellence, Powered by Chemistry.
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Grace Fine Chemical Manufacturing Services
Grace’s Fine Chemical Manufacturing Services (FCMS) is a North American contract development and manufacturing organization (CDMO) with decades of experience partnering with biotechs and pharma companies to solve complex chemistry challenges and seamlessly scale your small molecule project, from early development through commercial manufacturing and every phase in between. We offer development and manufacturing support for RSMs, intermediates, peptide building blocks, and custom active pharmaceutical ingredients (APIs) at our integrated U.S.-based facilities.
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Lonza
Lonza is a preferred global partner to the pharmaceutical, biotech and nutrition markets. We work to enable a healthier world by supporting our customers to deliver new and innovative medicines that help treat a wide range of diseases. We achieve this by combining technological insight with world-class manufacturing, scientific expertise and process excellence. Our unparalleled breadth of offerings enables our customers to commercialize their discoveries and innovations in the healthcare industry.
MilliporeSigma
With decades of expertise, we deliver preclinical to commercial success for your small molecule API program through a consultative and phase appropriate approach. With Millipore® CTDMO Services, tap into our global network to seamlessly execute your custom API projects. From conception to commercialization, we tackle the toughest small molecule API synthesis challenges from grams to commercial quantities.
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Nanoform
Nanoform is an innovative nanoparticle medicine enabling company. Nanoform works together with pharma and biotech partners to improve the lives of patients globally by overcoming drug development and delivery challenges through its game-changing nanoforming technologies, novel formulation capabilities and GMP manufacturing facilities. The company’s dedicated, multi-disciplinary team has a combined experience of launching 100+ medicines.
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PCI Pharma Services
PCI Pharma Services is an integrated full service provider, a proven and trusted partner to leading companies in the global healthcare industry. We offer unparalleled expertise and experience in taking compounds from the earliest stages of development through to successful commercialization, delivering speed-to-market and commercial success for our customers.
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Pharma Expanse
Pharma Expanse is a leading provider of contract development and manufacturing services, supporting manufacturing of RSMs, APIs, Drug Product, and Cell Therapies. Pharma Expanse has drug product capabilities across a number of modalities including small molecules, biologics, ADCs, peptides, and nucleic acids (mRNA). Cell Therapy capabilities include cell line development, master cell banking, and GMP manufacturing of allogeneic induced Pluripotent Stem Cells (iPSCs) for oncology and regenerative medicine.
The Pharma Expanse network currently spans across 20 manufacturing sites in 8 countries and can support discovery, preclinical, clinical, and commercial programs for New Chemical Entities (NCEs).
Praxis Packaging
Praxis is a leading contract packaging organization serving the pharmaceutical, biotech, animal health, medical device, nutritional and personal care sectors. With over 35 years of experience, Praxis provides solid dose bottling and blistering, DSCSA serialization and aggregation services, liquid filling, and a variety of secondary packaging solutions with speed, agility, and quality.
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Siegfried
Siegfried is a leading contract development and manufacturing organization with a global network of 16 production sites across the US, Europe, China and Australia. With more than 150 years of experience, we are taking your innovations to industrial scale.
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SK pharmteco
SK pharmteco’s mission is to build strong partnerships that deliver life-saving therapies and improve patient outcomes. With seven global facilities, we support the entire product lifecycle, from development to commercial manufacturing, with a collaborative “One Team” approach focused on transparency and trust. Offering CDMO services for small molecules, cell and gene therapy, and analytical testing—connect with our experts today!
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TCP Analytical
TCP Analytical supports small molecule API manufacturers with high-purity chemicals, cGMP production capabilities, and custom material solutions. Barker Pharma capabilities include inorganic salts, acids and bases, buffers, excipients, electrolytes, custom liquid formulations, and specifications tailored to regulated production needs. Additional TCP resources, including Reagents, LabChem, and Tangram Chemical, can support analytical, laboratory, and specialty chemical requirements from development through scale-up activities and commercialization planning support
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X-Chem
X-Chem is redefining small molecule drug discovery through a powerful combination of computational sciences, discovery chemistry and data-driven insight. As the pioneer and global leader in DNA-encoded library (DEL) technology, X-Chem provides the foundation for smarter hit identification, accelerated lead progression and greater confidence in early discovery.
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