Insights On Drug Discovery

  1. Allele-Selective Editing Of mHTT Results In Protein Reduction 5/28/2025

    Review the data presented in this slideshow to understand how LETI-101’s precise gene editing technology and promising preclinical data are being used to advance Huntington’s Disease treatment.

  2. Innovations In Hybridoma-Based Therapeutic Antibody Discovery Against Type 1 Transmembrane Proteins 5/23/2025

    Leverage the PentaMice®-powered hybridoma discovery and humanization platform to develop high-affinity, cross-reactive monoclonal antibodies against Type I transmembrane protein targets.

  3. Antibody-Based Drug Discovery At The Speed Of Light 5/23/2025

    Review this end-to-end workflow, including First-to-Human antibody development strategies, the use of the PentaMice® platform for targeted immunization, and the precision of single B cell screening.

  4. In Vitro/In Vivo Permeability: A 4-Cell Line Study 5/21/2025

    Evaluate drug absorption potential across diverse cell barriers and transporter systems using our comparative permeability studies with a variety of cell lines and standard compounds.

  5. Preclinical Model Of Post- Incisional Pain For Efficacy Testing Of Novel Therapeutics 5/16/2025

    Explore how validated preclinical models of incision-induced pain can accelerate the development of effective therapies for postoperative pain by closely mimicking human pain responses.

  6. Modelling TPDs Utilizing Computational And Medicinal Chemistry Approaches 5/16/2025

    Through a carefully executed strategy, see how we identified novel degrader molecules with the right physicochemical properties to achieve robust degradation of the target Protein of Interest (POI).

  7. Effect Of Methylprednisolone On The Systemic Lupus Erythematosus (SLE) In Murine Models 5/13/2025

    Leverage the MRL/lpr lupus mouse model to evaluate the effectiveness of potential SLE treatments, like Methylprednisolone, in managing key symptoms such as proteinuria and autoimmune responses.

  8. CFA-Induced Inflammatory Pain Model For Testing Anti-Inflammatory Compounds 5/13/2025

    Utilize clinically relevant preclinical models like the CFA-induced inflammatory pain model to advance the development and preclinical screening of effective therapies for managing inflammatory pain.

  9. Experimental λ-Carrageenan-Induced Inflammatory Pain Model For Testing Novel Analgesics 5/13/2025

    Explore reliable and reproducible λ-Carrageenan-induced inflammatory pain models for effective preclinical screening of promising analgesic candidates targeting chronic pain.

  10. Manual Whole-Cell Patch Clamp Assay For Screening NCE's Against Voltage Gated Ion-Channels 5/13/2025

    Ensure the cardiac safety of your drug candidates by leveraging manual whole-cell patch-clamping to assess their impact on hERG channel interactions and prevent potential QT prolongation risks.