Insights On Drug Discovery

  1. Exploring The Spatial Distribution Of mRNA-Lipid Nanoparticles Using MALDI MSI 4/23/2025

    Learn how leveraging high-resolution MALDI-MSI can advance the development of lipid nanoparticle-based therapies, uncovering spatial biodistribution, pharmacokinetics, and organ-specific variability.

  2. Distribution Of Standard-Of-Care Antituberculosis Drugs In Cynomolgus Macaque Lungs 4/23/2025

    Incorporate individual variability into PBPK models and build on HRZE lung distribution data in NHPs to optimize anti-TB dosing strategies and advance PK/PD research in tuberculosis.

  3. The Importance Of Sample Clean Up Demonstrated By Biomarker 4β-hydroxycholesterol 4/23/2025

    Learn how to strengthen biomarker assay reliability by optimizing derivatization and sample cleanup steps to eliminate contamination and improve robustness in 4β-hydroxycholesterol quantification.

  4. Multimodal Stratification Of Predictive Biomarkers In Head And Neck Cancers 4/23/2025

    By identifying and utilizing predictive biomarkers, learn how researchers can enhance the effectiveness and safety of cytokine-based immunotherapy in head and neck cancers.

  5. Uncovering Novel Therapeutic Targets In Immune Checkpoint Inhibitor Resistance 4/23/2025

    Use spatial proteomics and AI-driven cell segmentation to reveal tumor-immune interactions and discover new targets to overcome resistance to immune checkpoint inhibitors in metastatic cancer.

  6. A Pre-Clinical Study For Diet-Induced Obesity 3/28/2025

    Here, we look at the importance of using high-fat diet-induced obesity models to evaluate and compare the efficacy of anti-obesity and anti-diabetic treatments like rimonabant and liraglutide.

  7. Bleomycin-Induced Scleroderma Mouse Model For Preclinical Testing 3/27/2025

    Get an in-depth overview of the bleomycin-induced scleroderma model, detailing its key specifications and presenting significant findings observed following bleomycin administration in study animals.

  8. Preclinical Evaluation Of Novel Drug Candidates Against SLE In NZB/W F1 Mouse Models 3/27/2025

    Explore how the well-established NZB/W F1 mouse model enables the evaluation of novel anti-SLE therapeutics, providing critical insights into disease mechanisms and treatment efficacy.

  9. RSV Challenge Model For Anti-RSV Therapy 3/27/2025

    Utilize advanced rodent models to accelerate the preclinical testing of your anti-RSV therapies and vaccines, advancing the fight against this widespread respiratory infection.

  10. DSS-Induced IBD Mouse Model For Preclinical Drug Screening 3/27/2025

    Leverage our chemically induced murine model of Inflammatory Bowel Disease to accelerate your research on IBD and explore potential therapeutic interventions.