Insights On Drug Discovery

  1. How mRNA Technology Engineers Next-Generation Antibodies 4/26/2024

    Monoclonal antibodies (mAbs) stand as pivotal drug products and biochemical reagents in the 21st century. Explore how mRNA-encoded antigens could revolutionize antibody discovery.

  2. Novel Plasmid DNA-Encoded Poly(A) Tails For mRNA Synthesis 4/26/2024

    Here, we evaluate the stability of these variant poly(A) regions and the biological activity of the mRNA containing the variant poly(A) tails made from these templates.

  3. Effects Of mRNA Capping Technologies 4/26/2024

    This study compares two important mRNA capping technologies by evaluating the mRNA integrity, percent Cap1 content, dsRNA content, in vivo expression, and innate immune activation in mice.

  4. Assessing Doggybone DNA For In Vitro Transcription 4/26/2024

    In this study, we evaluated the performance of two dbDNA IVT templates, each encoding the same mRNA (firefly luciferase or Fluc), by looking at the mRNA purity and in vivo potency of the mRNA IVT’d from each template.

  5. Reduce Costly Scale-Up Problems 4/11/2024

    Scaling a new drug formulation from development to manufacturing often presents challenges, but there are ways to minimize deviations and streamline your transition.

  6. Host Cell Impurities, Bioassays, Micro-Flow Imaging 4/9/2024

    Ensuring the safety and efficacy of cutting-edge biopharmaceuticals hinges on meticulous quality control measures. Explore the role of qPCR and MFI in safeguarding drugs from potential contamination.

  7. The Role Of Early Characterization Studies In The Assessment Of Advanced Therapeutic Potency 3/21/2024

    Early product characterization can serve to uncover crucial information about an advanced therapeutic candidate, affording new insight into its CQAs and helping to shape better analytical assays.

  8. The Write Side Of AI: Augmenting Capabilities, Not Replacing Them 3/1/2024

    AI applications in medical writing are in their infancy, and the technology suffers several shortcomings including plagiarism, copyright infringement, and misinformation dissemination.

  9. Using GPS Engineering To Optimize Antibody-Based Drug Development 2/28/2024

    Explore the results collected when a platform designed with ML-guided GPS engineering was applied to develop a lead molecule targeting a mechanism in neuronal disease.

  10. Immunogenicity - Challenge For Protein Drugs 2/21/2024

    This presentation discusses the shift in pharmaceuticals from small-molecule drugs to protein biologics and the associated challenges, particularly the immunogenic response.