Insights On Drug Discovery

  1. Smart Scale-Up: Expanding Viral Vectors With Microcarrier Bead Technology 3/12/2025

    Scale up your manufacturing of adherent cell cultures used for viral vector-based treatments with the novel technologies needed to facilitate safe, rapid production.

  2. Innovations In Pregastric Absorption Drug Delivery And ODTs 3/10/2025

    Experts explore permeation enhancers for drug absorption, PBPK modeling for formulation design, and fast-dissolving ODTs shaping drug development.

  3. Discovery And Humanization Of High Affinity Therapeutic Antibodies Against Transmembrane Proteins 2/14/2025

    Here, we present a hybridoma-based antibody discovery and humanization strategy for a T1P target, utilizing Penta Mice immunization to generate monoclonal antibodies.

  4. Elucidating The Role Of IL-18 In NSCLC Integrated Analysis 1/23/2025

    Hear how imaging mass cytometry, CyTOF, and single-cell sequencing unlock the secrets of the tumor microenvironment. Discover new insights into IL-18 and its impact on non-small cell lung cancer.

  5. A Derivatization-Free LCMS Assay For 4β-hydroxycholesterol 1/23/2025

    Learn about a novel LCMS assay for 4β-hydroxycholesterol, a key biomarker for CYP3A activity. This derivatization-free method offers a faster and more efficient approach for clinical studies.

  6. Early Preclinical Development: A Successful Transition To cGMP Manufacturing 12/2/2024

    Explore the development steps that lead to an mRNA construct optimized for your requirements and that meets future-proof cGMP manufacturing requirements, thereby de-risking the development.

  7. Vector Technology For Improved Expression Control Of Biotherapeutic Proteins 11/19/2024

    Discover enhanced vector technology developed to enable better control of expression in cells, enhance titers, and improve expression stability for a range of biotherapeutic formats.

  8. Is Lipinski's Rule Of Five Still Relevant In Drug Development? 11/13/2024

    Some drugs violate multiple Ro5 elements but remain developable, while some molecules adhere strictly to the Ro5, but their properties are not conducive to development.

  9. cGMP-Ready Clonal HEK293 Cell Line For AAV, Lenti-, And Adenoviral Vectors 11/7/2024

    See how this advanced SKPT-HEK293 4G9 was able to provide a robust, CGMP-ready solution for efficient viral vector production, supporting a range of AAV serotypes and CAR-T Lenti-viral vectors for scalable manufacturing.

  10. Designing, Selecting, And Developing Bioconjugates For Clinical Success 10/24/2024

    Accelerate the development of complex bioconjugates to unlock new possibilities for targeted therapies and advance the next generation of precision medicine.