Insights On Drug Discovery
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Nonrodent Models: Minipig Specialty Capabilities
6/1/2023
The minipig's similarity to humans, availability, known disease status, and feasibility of genetic manipulation offer advantages over traditional species, impacting ethical considerations and cost of animals in biomedical research.
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Clinical Pathology In Target Animal Safety
6/1/2023
Clinical pathology reports optimize the results of animal studies, enable more informed, effective decision-making, and are essential for ensuring the safety of animals and humans alike.
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Which Studies Are Required As Part Of An IND Program?
5/16/2023
IND-enabling studies are the foundation of the drug development process, helping researchers predict safety concerns, estimate efficacious starting doses for clinical trials, and meet development timelines and milestones.
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Applying To Conduct A Clinical Trial
5/16/2023
Creating realistic expectations for regulatory considerations, necessary materials for IND submission, and approval timelines early in development is essential for reaching IND program milestones on-time and within budget.
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Laser-Induced Choroidal Neovascularization Model Of Macular Degeneration
4/19/2023
The laser-induced choroidal neovascularization (CNV) model is an established method to evaluate therapies for wet age-related macular degeneration (wet AMD), a leading cause of blindness in our senior population.
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In Vitro Toxicology Models
4/19/2023
Through the mission to develop and adopt replacements to animal testing, many acute toxicity tests are being effectively replaced by in vitro human, animal, and 3D tissue alternatives.
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Evaluating Multiple Vectors In A Single Eye
4/18/2023
Evaluating multiple novel AAV variants can be cost prohibitive. Learn how a new subretinal delivery model enables more responsible use of animal resources and achieves significant cost savings.
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Current Trends In Toxicology
4/18/2023
As developers balance safety concerns with pressure for accelerated development, hear experts discuss the innovations in culture systems and characterization that are enabling a safe, efficient pathway to successful IND.
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Microfluidic 3D Liver-On-Chip Model: Application In Genetic Toxicology
4/13/2023
Developing a toxicology battery with specific assays is crucial to mitigate risk. Examine this study's results and how the findings could help increase accuracy of assays in human models.
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Animal Models In Ocular Gene Therapy
4/13/2023
Various animal models — including non-human primates, rabbits, minipigs, and canines — present benefits and limitations for preclinical studies. Explore the insights to optimize the path to clinical trials.