Insights On Drug Discovery

31. Preclinical Model Of Post- Incisional Pain For Efficacy Testing Of Novel Therapeutics 5/16/2025

    Explore how validated preclinical models of incision-induced pain can accelerate the development of effective therapies for postoperative pain by closely mimicking human pain responses.

32. Modelling TPDs Utilizing Computational And Medicinal Chemistry Approaches 5/16/2025

    Through a carefully executed strategy, see how we identified novel degrader molecules with the right physicochemical properties to achieve robust degradation of the target Protein of Interest (POI).

33. Effect Of Methylprednisolone On The Systemic Lupus Erythematosus (SLE) In Murine Models 5/13/2025

    Leverage the MRL/lpr lupus mouse model to evaluate the effectiveness of potential SLE treatments, like Methylprednisolone, in managing key symptoms such as proteinuria and autoimmune responses.

34. CFA-Induced Inflammatory Pain Model For Testing Anti-Inflammatory Compounds 5/13/2025

    Utilize clinically relevant preclinical models like the CFA-induced inflammatory pain model to advance the development and preclinical screening of effective therapies for managing inflammatory pain.

35. Experimental λ-Carrageenan-Induced Inflammatory Pain Model For Testing Novel Analgesics 5/13/2025

    Explore reliable and reproducible λ-Carrageenan-induced inflammatory pain models for effective preclinical screening of promising analgesic candidates targeting chronic pain.

36. Manual Whole-Cell Patch Clamp Assay For Screening NCE's Against Voltage Gated Ion-Channels 5/13/2025

    Ensure the cardiac safety of your drug candidates by leveraging manual whole-cell patch-clamping to assess their impact on hERG channel interactions and prevent potential QT prolongation risks.

37. Exploring The Spatial Distribution Of mRNA-Lipid Nanoparticles Using MALDI MSI 4/23/2025

    Learn how leveraging high-resolution MALDI-MSI can advance the development of lipid nanoparticle-based therapies, uncovering spatial biodistribution, pharmacokinetics, and organ-specific variability.

38. Distribution Of Standard-Of-Care Antituberculosis Drugs In Cynomolgus Macaque Lungs 4/23/2025

    Incorporate individual variability into PBPK models and build on HRZE lung distribution data in NHPs to optimize anti-TB dosing strategies and advance PK/PD research in tuberculosis.

39. The Importance Of Sample Clean Up Demonstrated By Biomarker 4β-hydroxycholesterol 4/23/2025

    Learn how to strengthen biomarker assay reliability by optimizing derivatization and sample cleanup steps to eliminate contamination and improve robustness in 4β-hydroxycholesterol quantification.

40. Multimodal Stratification Of Predictive Biomarkers In Head And Neck Cancers 4/23/2025

    By identifying and utilizing predictive biomarkers, learn how researchers can enhance the effectiveness and safety of cytokine-based immunotherapy in head and neck cancers.