Experimental Chronic Constriction Injury (CCI) - Induced Neuropathic Pain Model

The International Association for the Study of Pain (2011) defines neuropathic pain as “pain caused by a lesion or disease of the somatosensory nervous system.” This condition can arise from damage anywhere along the neuraxis, including the peripheral nerves, spinal cord, or brain. Chronic neuropathic pain is often characterized by spontaneous pain, dysesthesia, paraesthesia, allodynia, and hyperalgesia. Due to its varied causes, symptoms, and underlying mechanisms, neuropathic pain remains challenging to manage effectively.

Preclinical animal models play a crucial role in elucidating the mechanisms of neuropathic pain and advancing therapeutic development. A wide range of models and administration routes enables researchers to tailor their studies for specific needs. These models have supported the successful preclinical evaluation of multiple therapeutic candidates. Here, we describe the development and pharmacological validation of a Chronic Constriction Injury (CCI)-induced model of neuropathic pain.