Drug Discovery Applications & Studies
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Novel Plasmid DNA-Encoded Poly(A) Tails For mRNA Synthesis
4/26/2024
Here, we evaluate the stability of these variant poly(A) regions and the biological activity of the mRNA containing the variant poly(A) tails made from these templates.
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Effects Of mRNA Capping Technologies
4/26/2024
This study compares two important mRNA capping technologies by evaluating the mRNA integrity, percent Cap1 content, dsRNA content, in vivo expression, and innate immune activation in mice.
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Assessing Doggybone DNA For In Vitro Transcription
4/26/2024
In this study, we evaluated the performance of two dbDNA IVT templates, each encoding the same mRNA (firefly luciferase or Fluc), by looking at the mRNA purity and in vivo potency of the mRNA IVT’d from each template.
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A Gene Expression System For Afucosylated Antibody Production
12/4/2023
Use a gene expression system that allows you to produce molecules that are 100% free of fucose and demonstrate increased potency, without compromising on titers, growth, stability, or product quality.
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Laser-Induced Choroidal Neovascularization Model Of Macular Degeneration
4/19/2023
The laser-induced choroidal neovascularization (CNV) model is an established method to evaluate therapies for wet age-related macular degeneration (wet AMD), a leading cause of blindness in our senior population.
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Evaluating Multiple Vectors In A Single Eye
4/18/2023
Evaluating multiple novel AAV variants can be cost prohibitive. Learn how a new subretinal delivery model enables more responsible use of animal resources and achieves significant cost savings.
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How Successful Tech Transfer Can Help Fast-Track NDA Approval
4/4/2023
Examine the first-time-right tech transfer and phase-3 registration batch manufacturing process which led to a biotech receiving NDA approval for its novel compound followed by a successful commercial manufacturing partnership.
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Partnering On An Innovative Hydrogel-Based Treatment For Glioblastoma
3/22/2023
Treatments for glioblastoma multiforme (GBM) are in high demand. Learn more about the new possibilities for increased dosing and diffusion capabilities offered by nanoformed APIs.
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Next Generation Sequencing For Adventitious Agent Detection In Cell Banks
2/23/2023
NGS-based methods for agnostic broad range detection are suitable options to augment or replace current virus testing methodology. Explore a NGS AAT method for cell line characterization and more.
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BEH C18 Batch-To-Batch Robustness For The Analysis Of Rosuvastatin And Impurities
6/30/2022
The main goal of this study is to investigate the long-term batch-to-batch reproducibility of 10 different lots of XBridge BEH C18 Columns. Discover the findings of this study.