Laser-Induced Choroidal Neovascularization Model Of Macular Degeneration In Nonhuman Primates And Rodents

The laser-induced choroidal neovascularization (CNV) model is an established method used to evaluate therapies for wet age-related macular degeneration (wet AMD), a leading cause of blindness in our senior population. Study design is flexible, factoring in the nature of the compound and its intended clinical regimen. Species selection may be based on compound activity, delivery method and/or phase of development.

Fluorescein angiography (FA) images are graded semi-quantitatively, and the amount of leakage is compared between control and treated eyes. As a second-tier evaluation, leakage area, normalized to fluorescent intensity, may be determined with image analysis software. In vivo FA is advantageous due to the potential for sequential evaluations over several weeks.

Download the Application Note in PDF to examine the efficacy of this model.