Drug Discovery Applications & Studies
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A Phase I Study Allowing Clinical Screening Of Multiple Solubility-Enhancement Formulation Technologies
3/7/2022
The study was designed to assess the clinical performance of prototype formulations, assess food effect and dose linearity of a selected formulation, and the impact on exposure in subjects taking proton pump inhibitors (PPI).
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A Clinical Assessment Of Delayed-Release Coated Capsule Compositions For Regional Gastrointestinal Delivery Using Gamma Scintigraphy
3/7/2022
Gamma scintigraphy was used to evaluate GI transit and release from 3 capsule prototypes with different coating systems; data on pH, temperature and pressure during GI transit was obtained and correlated.
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An Integrated Radiolabelled Study: Determine Mass Balance Metabolite Profile & Absolute Bioavailability
3/3/2022
The study assessed the absorption and disposition of nolasiban after oral and IV administrations and enabled determination of mass balance, routes and rates of excretion and metabolism and absolute bioavailability.
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Characterizing Injection Factors And Their Impact On System Function
2/9/2022
The transition of intravenous in-clinic chronic disease therapies to large volume subcutaneous injections in alternate settings has created an evolving roster of new formulations and treatment options.
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N-Linked Glycan Analysis For Complex Glycoproteins
12/20/2021
An established cell line and a bench-scale manufacturing process for a complex glycoprotein produced high quality material but had a low yield and was not scalable.
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Capture Of Histidine-Tagged Molecules Using Biacore His Capture Kit
10/21/2021
Find recommendations for immobilization of histidine-tagged molecules (ligands) by capture to an anti-histidine antibody covalently coupled to a sensor chip surface.
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How Collaboration Helped A Global Biopharma Fast-Track Novel Molecule Development For Global Licensing
9/2/2021
Discover how a Pharma-CRO partnership can extend beyond company borders into wholistic drug development activities for global licensing.
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Seahorse Bioscience Keeps Product Development Information In Sync With Omnify Empower
6/9/2015
Seahorse Bioscience provides analytical instruments, biomanufacturing systems, and consumable labware products for biological research and drug discovery. Seahorse technology is used to advance understanding of the role of cell metabolism in neurodegeneration, aging, cancer, cardiovascular, cell physiology, toxicology and hepatobiology, immunology, infectious diseases, mitochondrial diseases, model organisms, obesity, diabetes, metabolic disorders, screening, and translational medicine.
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Informatics For Neglected Diseases Collaborations
4/20/2011
Many different public and private organizations from across the globe are collaborating on neglected diseases drug-discovery and development projects with the aim of identifying a cure for tropical infectious diseases.
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Conjugating Antibody To Drug Using Novel Technology For Better ADCs
Explore how a novel conjugation technology is enabling streamlined and cost-efficient production of antibody-drug conjugates (ADCs), driving the development of effective targeted cancer therapies.