INSIGHTS ON DRUG DISCOVERY

• Quality Matters – SEC Analysis For Antibody Aggregates

  Size exclusion chromatography is the go-to analytical method for therapeutic protein drugs. This article describes the factors affecting the reproducibility of columns and how you can minimize column variation.

• Cell-Based Assays In A GMP Environment: Approaches For Clinical And Commercial Stability Studies

  This presentation demonstrates that in vitro, cell-based assays is an indispensable tool to quantify the biological activities, and to support the potency tests, for bio therapeutics.

• Industry 4.0 Connects Machines And Data

  By applying remote monitoring, advanced modeling, and optimization of manufacturing processes, Industry 4.0 offers process reliability and product quality through connecting machines and data.

• Amgen’s Digital Transformation: Link Suppliers' Raw Material Data To Patients

  Using its Supplier Relationship Excellence program, Amgen opened the lines of communication with suppliers and created a feedback loop where data can be shared to optimize operational performance. 

• How Biogen Integrated PAT With End-To-End Supply Chain Transparency

  To drive dependable critical process control requirements, Biogen explored novel strategies to increase process and raw material control and optimize communication of data throughout the supply chain.

• Unlock Oral Delivery Potential For Macromolecules With A Parallel Screening Approach

  Salmon Calcitonin is a peptide with poor oral bioavailability. To assess its potential for oral delivery, Catalent conducted a parallel screening with 2 different technologies targeting duodenal and sublingual biological barriers respectively. Lipid formulations and lyophilized tablet formulations were developed in parallel. Subsequently, based on the animal PK study data, the optimal formulation and dose form was identified which shows the oral bioavailability of Salmon Calcitonin was increased by more than 20 times.

• Optimizing Your Plate-Based Assay Workflows

  Using workflow based software solutions to guide scientists through various processes in low to high throughput screening campaigns.

• Leverage The Internet Of Things Within The Laboratory

  As science-based organizations look to leverage the internet of things (IoT) within the laboratory, careful consideration must be given to available technologies, data formats, and platforms. 

• Electronic Lab Notebook Supports Scientific Knowledge Management In R&D

  One tool holds a unique position among R&D informatics systems -- electronic laboratory notebooks (ELNs). ELNs both produce data and consume information and are particularly powerful.