INSIGHTS ON DRUG DISCOVERY

• Potent Immune Response With Vernal’s LNP-mRNAs

  As mRNA medicine continues to evolve, understand how trusted manufacturing partners will continue to play a pivotal role in translating innovative concepts into clinical reality.

• How mRNA Technology Engineers Next-Generation Antibodies

  Monoclonal antibodies (mAbs) stand as pivotal drug products and biochemical reagents in the 21st century. Explore how mRNA-encoded antigens could revolutionize antibody discovery.

• Novel Plasmid DNA-Encoded Poly(A) Tails For mRNA Synthesis

  Here, we evaluate the stability of these variant poly(A) regions and the biological activity of the mRNA containing the variant poly(A) tails made from these templates.

• Effects Of mRNA Capping Technologies

  This study compares two important mRNA capping technologies by evaluating the mRNA integrity, percent Cap1 content, dsRNA content, in vivo expression, and innate immune activation in mice.

• Assessing Doggybone DNA For In Vitro Transcription

  4/26/2024

  In this study, we evaluated the performance of two dbDNA IVT templates, each encoding the same mRNA (firefly luciferase or Fluc), by looking at the mRNA purity and in vivo potency of the mRNA IVT’d from each template.

• Reduce Costly Scale-Up Problems

  4/11/2024

  Scaling a new drug formulation from development to manufacturing often presents challenges, but there are ways to minimize deviations and streamline your transition.

• Host Cell Impurities, Bioassays, Micro-Flow Imaging

  4/9/2024

  Ensuring the safety and efficacy of cutting-edge biopharmaceuticals hinges on meticulous quality control measures. Explore the role of qPCR and MFI in safeguarding drugs from potential contamination.

• The Role Of Early Characterization Studies In The Assessment Of Advanced Therapeutic Potency

  3/21/2024

  Early product characterization can serve to uncover crucial information about an advanced therapeutic candidate, affording new insight into its CQAs and helping to shape better analytical assays.

• The Write Side Of AI: Helping Hands, Not Replacement Plans

  3/1/2024

  AI applications in medical writing are in their infancy, and the technology suffers several shortcomings including plagiarism, copyright infringement, and misinformation dissemination.