Insights On Drug Discovery

  1. NIH:OVCAR-3 Human Ovarian Cancer Model 8/26/2025

    Review several studies using the NIH:OVCAR-3 model of human ovarian cancer in the subcutaneous setting in NSG mice with multiple standard agents and vehicles. This model has shown reproducible growth.

  2. An Alternative Genetic Engineering Tool In CHO Cells 8/15/2025

    Discover how transposon technology is being reimagined as a precise genetic engineering tool to create high-performing CHO cell lines for biotherapeutic production with enhanced metabolic and glycan profiles.

  3. Designing IND-Enabling Toxicity Studies For Complex Drug Modalities 8/6/2025

    Learn more about how we adapt and enhance conventional small molecule IND-enabling studies to align with the evolving demands of modern therapeutics.

  4. Discovery Studies: An Agile Approach To Early Data For Quicker Decisions 8/6/2025

    This scientific journal explores the value and characteristics of discovery research and presents two case studies on biodistribution under specific experimental conditions.

  5. Random & Semi-Targeted Integration In Cell Line Development 8/5/2025

    Compare random and semi-targeted integration strategies for stable cell line development, highlighting their impact on expression consistency, scalability, and regulatory considerations.

  6. Accelerating Gene Therapy Development For NEDAMSS 7/15/2025

    Discover how one family's race against time led to the creation of a groundbreaking gene therapy for their daughter, just 14 months after her ultra-rare disease diagnosis.

  7. Solving The Inhalation Puzzle: A CDMO's Guide To Dry Powder Development 7/9/2025

    Gain guidance on the choice of formulation, excipients, and the micronization technologies offered by CDMOs, and learn about current encapsulation technologies for inhaled products.

  8. New Approaches To Tailored Release Profiles 7/7/2025

    Tailored drug release is evolving from formulation tactic to precision therapy strategy, optimizing timing, site, and rate of delivery for improved patient outcomes.

  9. Securing A Treatment Through Grit And Collaboration 7/3/2025

    Discover how one family defied the odds—bringing a lifesaving gene therapy from idea to treatment in just 14 months after a devastating rare disease diagnosis.

  10. Creating Your ADC Supply Chain 6/26/2025

    Antibody-drug conjugates (ADCs) are on the rise. Supply chains to serve ADC developers can be complicated, and spread out. Reza Oliyai has some key interpretations of how these therapies can string together optimal - and at times far-reaching - supply chains.