Outsourced Pharma App Notes & Case Studies
-
3 Steps To Optimize The Fed-Batch Process For mAb Production
6/2/2021
We describe a straightforward way to achieve high-performing fed-batch process for a knockout cell line. This workflow improved titers 500% compared with CHO cell culture in basal medium.
-
Biotech Enables Accelerated Scale-Up Of A Spray-Drying Program
3/4/2022
A virtual biotech, focused on the development and commercialization of a product to treat advanced solid tumors, partnered for the development, clinical trial supply, and scale-up of a spray-drying program.
-
Process Development For AAV Vector Production In Suspension Cells
11/19/2021
Review experiments for the adaptation of the HEK293 suspension cell line for transient transfection and scalable adeno-associated virus (AAV) production.
-
Application Of A Sf-Rhabdovirus-Negative Platform For AAV Production
3/10/2023
Discover a two-part system comprising a proven Sf-9 cell line devoid of Sf-rhabdovirus and a chemically defined medium engineered for it. Explore performances of this medium for AAV2 production.
-
What’s Happening In Cell & Gene Therapy Development?
2/8/2022
This ISR report provides support and direction for innovator companies looking to outsource aspects of their cell and gene therapy manufacturing and development through shared research highlights.
-
Reduce Supply Chain Disruptions With Second Sourcing
3/16/2023
Follow one CDMO's collaboration with Thermo Fisher Scientific to combat supply chain risks after one of the high-volume raw materials critical to their manufacturing process experienced a global shortage.
-
Biologics Outsourcing Differences By Company Size
6/14/2022
ISR split the data from its most recent Biologic API CDMO Benchmarking report by large and non-large respondents to highlight the differences in outsourcing preferences and practices.
-
Quantitation Of Retrovirus-Like Particles (RVLPs) In CHO Derived Products
3/11/2022
Review key methods which are applied to ensure safety of such recombinant proteins, with a focus on alternate and superior methods to the standard transmission electron microscopy (TEM) method.
-
In-House Manufacturing: Key To Driving A Diabetes Vaccine?
1/28/2022
Increasing constraints on today’s supply chain from the COVID-19 pandemic mean drug companies must secure strategies that can ensure product delivery in the face of these challenges.
-
Industry 4.0 Paving The Way For More Efficient Processes
9/9/2021
From sensors and software to data-based services throughout production, Industry 4.0 solutions are opening new potential in terms of transparency, quality, safety and efficiency.