Outsourced Pharma App Notes & Case Studies

1. SYLOID® Silica For Enhanced Micronization Efficiency 10/7/2025

   Here, we demonstrate how adding small amounts of SYLOID® mesoporous silica to Cholesterol before jet milling can enhance processing efficiency, boost yield, and improve micronization performance.

2. mRNA Manufacturing With Fed-Batch In Vitro Transcription 2/13/2026

   A milliliter-scale approach to IVT optimization reveals how controlled feeding, precise pH management, and real-time monitoring can boost mRNA yield and streamline scale-up to larger bioreactor volumes.

3. Seed Train Intensification Using High Cell Density Cryopreservation 8/11/2025

   Streamline your upstream bioprocessing with seed train intensification. Discover how high cell density cryopreservation reduces scale-up time, boosts consistency, and enhances manufacturing flexibility.

4. Expanding The OSD Toolbox: An Industry Approach To Adsorb Lipids Onto Powder Substrates 12/11/2024

   Explore innovative solutions for improving the solubility and bioavailability of poorly soluble compounds in solid oral dosage forms to enhance drug delivery and therapeutic effectiveness.

5. Enabling Complex Phase IIa Dosing Through Flexible Clinical Packaging Design 5/6/2026

   Discover how flexible, patient‑centric clinical packaging supports complex Phase IIa dosing while protecting timelines, ensuring compliance, and avoiding costly primary packaging changes.

6. Optimized Processes: A Guide To Lyophilization Cycle Development 6/25/2024

   Review the essential phases of the lyophilization cycle — freezing, primary drying, and secondary drying — and critical success factors to achieve optimal product quality and stability.

7. Cell Retention Technology And Specialized Cell Culture Media 8/11/2025

   Explore how perfusion technology is transforming upstream bioprocessing by boosting productivity, reducing costs, and enabling process intensification while overcoming cell retention challenges.

8. Mechanochemistry- Enabled Solid-State Stress Testing 5/6/2026

   Discover how solvent‑free, solid‑state stress testing speeds degradation studies, yields realistic impurity profiles, and provides earlier, material‑efficient insight into drug stability and risk.

9. Optimizing Bispecific Antibody Expression Via Multi-Omics Analysis And Vector Redesign 12/17/2025

   Discover how diagnosing ribosome pausing sites and optimizing codon usage dramatically improves bispecific antibody titers, turning difficult-to-express candidates into viable therapeutics.

10. Formulation Development Of Enterically Protected Spray Dried Dispersions 11/17/2025

    Adrulipase spray-dried dispersions were evaluated to create an orally delivered, enteric-protected enzyme. The lead formulation provided the best acid protection, rapid release, and stability.