Outsourced Pharma App Notes & Case Studies

1. Spray-Dried Dispersions Enable Local Delivery For Lung Cancer 4/20/2021

   Spray drying is a useful particle engineering technique that can deliver the particles within the necessary specifications and can therefore be used to manufacture dry powder inhaler treatments. Learn more about spray drying, and discover two case studies detailing its success.

2. Meet The Scientist — Bryan Braxton, Ph.D. 2/5/2021

   Bryan Braxton has a friendly, grounded demeanor and a scientific mind that creates solutions for our most complex aseptic development projects. But how did these two traits combine in the same person?

3. Dissolution Development Of Parvulet® Technology Oral Tablets 4/19/2021

   With the development of a dissolution method for a patented oral dosage form capable of being dispensed to patients in tablet or powder formats and converted into a semi-solid through activation with water, it is necessary to study the possible dissolution artifacts.

4. Scale-Up Of CHO Cell Fed-Batch Cultures 2/21/2020

   This application note compares cell growth and recombinant protein production of multiple CHO cell clones when cultured in HyClone ActiPro basal medium and Cell Boost 7a and 7b feeding supplements.

5. Microcaps® Outperforms Standard Bead Intermediate Formulations 4/19/2021

   A particularly bitter pediatric macrolide in powder form had needs beyond just taste masking, including fast release due to a narrow absorption window, a smooth syrup mouthfeel acceptable to children and infants, and drug loading suitable for its high dose.

6. The Value Of A BD Integrated System For Combination Products 7/24/2020

   The growing complexity and regulatory rigour of combination products has called for increasingly innovative delivery devices. This article looks at the advantages of using an integrated system for these drug-device combination products rather than sourcing components from different suppliers.

7. Probing The Source Of An Unstable Impurity And Controlling Its Formation At Release 4/19/2021

   A critical step in an extended-release drug product analysis is the extraction during impurity and assay sample preparation. When both the drug substance and the impurity are unstable, this is especially challenging.

8. How Should You Prepare For Foreign FDA Inspections During COVID-19? 2/25/2021

   As the COVID-19 pandemic continues, it is important to understand the expectations of regulators about how to facilitate paper-based facility inspections in lieu of those performed on site.

9. How To Accelerate Global Market Growth With Agile Product Sample Pouching Programs 4/6/2021

   A market-leading consumer health products division of a multi-national pharmaceutical company sought to grow their brand with an innovative, new vitamin product. This launch would involve complimentary sample pouches that could be distributed across a range of channels to reach as many consumers as possible. That is where Jones Healthcare Group stepped in.

10. Technology Selection To Enhance Bioavailability 7/23/2020

    Bioavailability challenges are among the toughest problems faced by today’s formulators. Most of the prospective drugs in pharmaceutical pipelines today have low solubility, which means the active therapeutic ingredients can’t be absorbed when patients take them orally. This paper gives an overview of obstacles to bioavailability and summarizes the Lonza technology selection process.