Accelerating Bulk Harvest Testing Using The Blazar® CHO Animal Origin Free Virus Panel For Rapid Adventitious Virus Detection

The biologics industry is continually developing new manufacturing approaches designed to improve yield, reduce processing time and costs, and harness the power of digitalization to increase process efficiency. In line with these advancements, regulators are publishing guidance on the use of new technologies for adventitious agent detection, which can support progress in biomanufacturing by offering increased breadth of detection, improved sensitivity, and faster timelines. This white paper describes the Blazar® CHO Animal Origin Free (AOF) panel for rapid adventitious virus detection, a degenerate PCR-based approach to broad virus screening. In appropriate situations, the panel can be used for testing bulk harvest material derived from CHO cells and can be combined with other rapid methods to significantly reduce the overall turnaround time for a bulk harvest testing package.