OP White Papers - random

  1. mRNA Therapeutic Development Through Enhanced IVT Capping Efficiency 4/16/2025

    See how Codex HiCap RNA Polymerase supports the production of high-performance synthetic mRNA, paving the way for next-generation mRNA therapies.

  2. Nucleic Acid-LNP Ultrafiltration And Diafiltration 5/5/2026

    Downstream filtration can make or break LNPs at scale. See how membrane format, loading, and shear affect recovery and stability — and how alternative TFF lowers scale‑up risk.

  3. Manufacturing Of Cytotoxic And Non-Cytotoxic Drugs In A Multiproduct Facility 10/16/2024

    The experience and expertise of the CMO is crucial to avoid the risk of cross-contamination of the drug product, as failures or weaknesses in this process can pose risk to the end-user.

  4. Performance Characteristics Of The Mobius® ADC Reactor For Conjugation 10/22/2024

    Explore results from a series of studies evaluating the mixing performance of an innovative ADC reactor during the conjugation step utilizing a model fluid.

  5. The Case For Non-Viral Circular Single-Stranded HDR Donors 8/13/2026

    Enable efficient, low-toxicity genome editing without viral vectors. This cell-free circular ssDNA platform preserves stem cell fitness while supporting scalable manufacturing.

  6. Unlocking Durable Allogeneic Cell Therapy 5/13/2026

    Advances in genome engineering and immune evasion are enabling scalable, durable allogeneic cell therapies, overcoming rejection challenges and expanding potential treatments across diverse diseases.

  7. Spray Dry Biologics For Oral Dosage Forms 5/15/2026

    Spray drying enables stable oral delivery of biologics by creating protective dry powders, improving bioavailability, stability, and targeted release compared with traditional formulation methods.

  8. Starting With The End In Mind 7/16/2026

    Complex biologics need scalable, GMP-ready development from the start. Early decisions, scientific continuity, and strong partnerships help reduce delays and rework.

  9. Methods For Determining Equipment Capability Of Freeze-Dryers 10/16/2024

    Observe two experimental methods for determining choked flow: the minimum controllable pressure method and the choke point method.

  10. A Scalable Platform To Revolutionize Gene Therapy Manufacturing 11/22/2024

    Discover how our innovative rAAV production platform can revolutionize your gene therapy pipeline with unparalleled yield, quality, and scalability.