Featured Articles

  1. Considerations For Developing The Recirculation/Perfusion Process 6/6/2024

    Learn about the recirculation and perfusion processes made possible by single-use, fixed-bed bioreactors designed for scaling up adherent cell culture processes.

  2. Genomic Medicine Demands Manufacturing Innovation 5/28/2024

    The promise of novel therapeutic modalities can only be realized when effective science is paired with efficient manufacturing to provide cost-effective therapies to patients in need.

  3. A Different Approach To Adeno-Associated-Virus (AAV) Clarification 5/10/2024

    Knowledge of the feed stream, process constraints, and goals, makes selecting depth and membrane filter combinations for preliminary bench-scale filterability studies possible.

  4. Tips For Viral Vector Production 4/16/2024

    Learn about how meticulous purification optimization can maximize recovery and impurity removal by leveraging scalable downstream technologies to meet regulatory and process economy requirements.

  5. What Is A Viral Vector? 4/16/2024

    Review a novel adenovirus production process that offers scalable, single-use equipment-compatible solutions, reducing production time and cross-contamination risks.

  6. Three Key Considerations For Optimizing Process Development 3/25/2024

    When it comes to process development, timing, technology, and partners all merit careful consideration. Explore expert insights into these three crucial factors.

  7. Navigating Cell Therapy Process Development 3/25/2024

    Equip yourself with the knowledge necessary to make well-informed decisions by exploring the main challenges and considerations inherent in cell therapy process development.

  8. A Scalable Single-Use Two-Step pDNA Purification Process 3/6/2024

    Evaluate the performance of a single-use two-step plasmid purification process, and see how it compares to the existing three-step purification method.

  9. High-Titer rAAV Production In Bioreactors Using Producer Cell Lines 3/6/2024

    Here, we detail the upstream process development and optimization for an AAV8-GFP proof-of-concept (PoC) producer single cell clone (SCC) in both batch and perfusion modes.

  10. Safer AAV Through Reduced Host-Cell DNA Encapsidation 3/6/2024

    While most hcDNA molecules outside AAV particles can be eliminated during downstream processing, encapsidated hcDNA molecules remain largely undetectable. Learn how to overcome this critical issue.