Discovery Research Articles

81. Plasmid DNA Capabilities 2/17/2022

    Our customized pDNA CDMO services offer research-grade, high-quality, and GMP materials.

82. CHEF1™ Expression Technology 2/17/2022

    The platform accelerates development of cell lines for cGMP production by using robust procedures and reliable raw materials, including chemically defined media, adapted Chinese hamster ovary (CHO) cells, and proprietary expression plasmids, to rapidly produce high levels of recombinant protein.

83. Adherent Versus Suspension Processes For Viral Vector Manufacturing 2/3/2022

    In adherent cell culture, cells are grown while attached to a substrate as monolayers. In suspension cell culture, cells are free-floating in the culture medium. Which offers more benefits?

84. Formulation Development Strategy For Early Phase Human Studies 1/27/2022

    Determining bioavailable formulation for animal PK, GLP toxicity, first-in-human, and first-in-patient is challenging. Drug delivery systems are usually used for poorly soluble and bioavailable compounds.

85. Testing Cell Line Development Technology Platforms In Parallel 1/18/2022

    Access to multiple cell line development platforms — and the option to test them against one another — can minimize project risk, optimize titers, and differentiate vendor partners.

86. Automated Bag Thawing System For CAR-T Cell Therapy Manufacturing 1/11/2022

    The performance of the VIA Thaw CB1000 is compared to thawing in a water bath. The VIA Thaw™ dry thawing system shows comparable performance to a water bath with less handling.

87. N-Linked Glycan Analysis For Complex Glycoproteins 12/20/2021

    An established cell line and a bench-scale manufacturing process for a complex glycoprotein produced high quality material but had a low yield and was not scalable.

88. Crystallization Of Challenging Pharmaceutical Targets To Aid Drug Discovery 12/13/2021

    Discover a few successful strategies used when growing crystals of challenging pharmaceutical targets to aid drug discovery and two case studies performed by an experienced team of crystallographers.

89. Raman vs. MIR Spectroscopy For Mammalian Cell Culture Monitoring 12/9/2021

    A direct comparison between the two technologies was conducted to investigate which system is more suitable for analyzing mammalian cell culture(s).

90. Process Development For AAV Vector Production In Suspension Cells 11/19/2021

    Review experiments for the adaptation of the HEK293 suspension cell line for transient transfection and scalable adeno-associated virus (AAV) production.