Catalent Biologics Content
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Ensuring Success In Early Biopharmaceutical Formulation Development
6/10/2019
Biopharmaceuticals tend to be highly unstable. A pilot formulation study at the early drug substance development stage can make things considerably easier at the manufacturing stage.
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Solution To Ensure Quantity And Quality Of The Excipient Polysorbate-80 In Drug Formulations
6/10/2019
Excipients are valuable substances used to improve stability and potency, but their sourcing and stability can be a challenge. A two-method solution to evaluate one such excipient, PS-80, for quantity and quality has multiple applications for drug developers looking to utilize this in their final product.
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Comparing Batch Versus Continuous Modes
6/10/2019
This case study compares the productivity of purifications running in batch versus continuous mode. Both Protein A capture resins demonstrated increased productivity with lower buffer volume in continuous mode.
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ICP-MS Analysis Of Multiple Trace Elements In Industrial Cell Lines
6/10/2019
This poster presents an approach using trace-level multiple-element analysis through inductively coupled plasma-mass spectrometry to support upstream process development and batch quality control.
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A Novel Purification Tool's Effects On HCP Reduction, Turbidity
6/10/2019
This study involved a DoE approach to investigate effects of pH and conductivity on the turbidity, yield, and impurity clearance of the Emphaze™ AEX Hybrid Purifier and efficiency of the Protein A capture step.
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High-Throughput Formulation Dev. For High-Concentration mAbs
6/10/2019
How a high-throughput, microwell plate platform can be used to economically screen a model IgG1 mAb at 120 mg/ml in 96 formulations while minimizing protein consumed and generating large amount of data.
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Strategies For Process Characterization, Late Phase Development
6/10/2019
We propose a stepwise approach for the definition and execution of Process Characterization for the production of a monoclonal antibody to improve the efficiency and effectiveness of the process.
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Achieving Unique Synergies In Antibody Expression
6/10/2019
This poster demonstrates how a cell line development technology combined with a platform for cell line selection shortens timelines and generates productive, stable, high expressing cell lines.
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Novel Analytical Techniques For Monoclonal Antibodies
10/25/2017
Learn how using an Octet-based Fc receptor panel may help achieve a faster assessment of monoclonal antibody functionality — well before the final molecule is selected.
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ADC Stands Out In The Crowd Of HER2-Targeted Conjugates
Due to its modularity, the SMARTag conjugation platform can be broadly applied to various disease contexts. It leverages ease of analytics and a critical combination of efficacy and tolerability.