Scale Your Process Directly From 3L To 2,000L Blindfolded

Time is of the essence.  In the biotech industry, you need to move quickly and use resources efficiently to advance a drug candidate into the clinic and ultimately onto the market. Being able to quickly produce a batch at the right time and at the right size is essential to support development and get to the finish line faster. We developed a strategy to enable a direct, efficient and robust tech transfer of a monoclonal antibody production process from a 3L bioreactor to 2000L without the need for any intermediate volumes. Our approach allowed us to achieve similar conditions for production at the 2000L scale as were developed for the 3L bioreactor. By leveraging our deep understanding of process dynamics and sophisticated Mobius® bioreactors, process scale-up from 3L bench scale bioreactors to 2000L becomes faster, more predictable, and consistent.  

Learn more from USP Production Team Leader, Cyril Rols from BioReliance® End-to-End Solutions, MilliporeSigma.