Scalability And Performance Of Mobius® iFlex Bioreactors

Biopharmaceutical manufacturers must produce a high-quality drug supply while reducing facility footprint and lowering production costs. Utilizing single-use bioreactors in intensified fed-batch and perfusion processes enables manufacturers to simultaneously meet these requirements and increase both manufacturing flexibility and product yields.

The Mobius® iFlex Bioreactors are versatile, single-use, stirred tank systems designed to support traditional and intensified fed-batch as well as perfusion cell culture applications. Their constant 2:1 aspect ratio simplifies the scaling of upstream bioprocesses. By providing increased flexibility and minimizing the number of vessels needed in a single process, these bioreactors effectively reduce facility footprint. They are engineered to maintain a constant power number across all system sizes, ensuring homogeneous mixing, optimal mass transfer, and reduced risk of shear associated with agitation. Experiments have shown that these bioreactors can achieve mixing times under 34 seconds and efficient gas transfer which is essential for cell growth, metabolism, and protein production. Additionally, they have effective CO₂ stripping capabilities, crucial for pH control. Read more to explore the performance of Mobius® iFlex Bioreactors in greater detail.