Non-GLP Toxicology
Source: Charles River
Charles River provides services in non-GLP bioavailability, pharmacokinetics and toxicity analysis.
Charles River provides services in non-GLP bioavailability, pharmacokinetics and toxicity analysis in addition to in vitroassays designed to assess the cytotoxic, genotoxic and cardiotoxic potential of candidate molecules.
Products and Services:
Acute Toxicity Testing
- Timed dosing and sampling
- Tissue and/or organ preservation
- Plasma and/or serum sampling
- Histology and pathology
- CBC with differentials
In vitro Cytotoxicity Testing
- Cell viability: ATP and MTS endpoint
- Membrane integrity: LDH endpoint
- Apoptosis: caspase-3/7 endpoint
Genotoxicity Testing
- BlueScreen assay
- MicroAmes assay
- Micro in vitro micronucleus test
- Cardiotoxicity Testing
- hERG channel blockade
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