Microfluidic 3D Liver-On-Chip Model: Application In Genetic Toxicology

Genetic toxicology assessments are required in many industries and play an important role in mitigating safety risks and bolstering product quality. Unfortunately, there is no single assay capable of detecting all potential toxicants, and regulatory agencies require a battery of tests to adequately assess a product’s genotoxicity. However, incorporating all assays into a single model enables an efficient, comprehensive assessment strategy which could improve safety measures and development efficiency simultaneously.

Developing a toxicology battery with high specificity assays is crucial to safeguard patient populations and reduce risk. While current batteries for rodent testing are comprehensive and widely accepted, they are not human and could be missing important elements that specifically impact human metabolism. Examine the results from this study of microfluidic systems by Charles River and how the findings could help increase accuracy of assays in human models.