Datasheet | February 4, 2009

Datasheet: In Vivo Cardiovascular Services

Source: Aptuit, Inc.

To meet ICH S7A and S7B guidelines, the effects of test substances on arterial blood pressure, heart rate and lead II ECG (RR, PR, QT, QTc intervals and QRS duration) can be explored in conscious Beagle dogs or Cynomolgus monkeys using chronically implanted telemetry devices. In addition to standard corrected QT intervals, a correction of the QT interval that is specific to each individual animal is derived on a study by study basis (QTcQ Interval) to improve the detection of any potential QT interval effect.

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