White Paper

How To Increase The Solubility And Bioavailability With Hot Melt Extrusion?

Source: AbbVie

By Brian Anderson

Hot Melt Extrusion (HME) is an enabling processing technology that dates back many decades in the plastics, food, and other industries, and has been applied in pharmaceuticals for nearly 30 years now. Pharmaceutical manufacturers choose HME to enable poorly soluble compounds. When executed properly, HME advances poorly soluble compounds in the development pipeline, without adding delays, cost, or significant post-processing activities, and can scale to commercial manufacturing.

HME offers many advantages to pharmaceutical manufacturers who face increasing complexity in the compounds being targeted, as well as pressures to lower costs and get to market ahead of the competition. In addition to increasing the solubility and bioavailability of poorly soluble compounds, HME is an economical and environmentally friendlier processing technology:

  • No use of solvents
  • Fewer processing steps (no time-consuming drying necessary)
  • Continuous operation
  • Ease and speed of processing
  • Highly reproducible
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