B41 Milestones
Date | B41 Milestones New Capability or Significant Enabling Investment |
|
1941-45 | Upjohn expansion program deferred due to wartime activities | |
1945 | Portage Road location selected for B41 after survey of alternatives | |
1946 | Construction of B41 by The Austin Company begins | |
1949 | First move-in to B41 | |
1951 | B41 fully occupied and operational | |
1953 | The era of steroid manufacturing begins in B41 with Cortef | |
1955 | First continuous filling/stoppering machine installed for Mix-O-Vial presentation (precursor of Act-O-Vial) | |
1957 | Mix-O-Vial brought to market | |
1970 | 20-year plan for the future of sterile manufacturing in B41 featuring minimum essential equipment located in controlled aseptic core | |
1969 | Freeze drying capability implemented in B41 | |
1971 | First fully-automated filling line | |
1974 | First high-speed vial filling line (Line 09) operational, featuring microprosseor control and automated check-weighing | |
1980 | Biologic sterile-injectable manufacturing begins | |
1983 | First expansion of B41 added - B259 control facility | |
1992 | Significant freeze-drying expansion and update in B41 | |
1995 | Upjohn merges with Swedish firm Pharmacia to form Pharmacia & Upjohn | |
1995 | Second expansion of B41 added - B392 microbiology lab addition | |
2000 | Pharmacia & Upjohn merges with Monsanto and Searle to create Pharmacia | |
2003 | Pfizer acquisition of Pharmacia | |
2009 | Aseptic Processing North facility approved and operational | |
2010 | First fully-automated inspection line (Line 09) featuring both vision and leak-detection capabilities | |
2014 | First serialized production lot released, demonstrating true track-and-trace capability | |
2018 | Warehouse moved from B41 to new B541 to make space for additional sterile-injectable manufacturing |
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