B41 Milestones
| Date | B41 Milestones New Capability or Significant Enabling Investment |
|
| 1941-45 | Upjohn expansion program deferred due to wartime activities | |
| 1945 | Portage Road location selected for B41 after survey of alternatives | |
| 1946 | Construction of B41 by The Austin Company begins | |
| 1949 | First move-in to B41 | |
| 1951 | B41 fully occupied and operational | |
| 1953 | The era of steroid manufacturing begins in B41 with Cortef | |
| 1955 | First continuous filling/stoppering machine installed for Mix-O-Vial presentation (precursor of Act-O-Vial) | |
| 1957 | Mix-O-Vial brought to market | |
| 1970 | 20-year plan for the future of sterile manufacturing in B41 featuring minimum essential equipment located in controlled aseptic core | |
| 1969 | Freeze drying capability implemented in B41 | |
| 1971 | First fully-automated filling line | |
| 1974 | First high-speed vial filling line (Line 09) operational, featuring microprosseor control and automated check-weighing | |
| 1980 | Biologic sterile-injectable manufacturing begins | |
| 1983 | First expansion of B41 added - B259 control facility | |
| 1992 | Significant freeze-drying expansion and update in B41 | |
| 1995 | Upjohn merges with Swedish firm Pharmacia to form Pharmacia & Upjohn | |
| 1995 | Second expansion of B41 added - B392 microbiology lab addition | |
| 2000 | Pharmacia & Upjohn merges with Monsanto and Searle to create Pharmacia | |
| 2003 | Pfizer acquisition of Pharmacia | |
| 2009 | Aseptic Processing North facility approved and operational | |
| 2010 | First fully-automated inspection line (Line 09) featuring both vision and leak-detection capabilities | |
| 2014 | First serialized production lot released, demonstrating true track-and-trace capability | |
| 2018 | Warehouse moved from B41 to new B541 to make space for additional sterile-injectable manufacturing |