Advanced Methodology Of PLGA-Based Parenteral Formulations

Sustained release drug delivery systems are designed to extend the therapeutic effect of a drug by gradually releasing it over an extended period from a carrier matrix. Among various polymeric carriers explored for this purpose, poly(lactic-co-glycolic acid) (PLGA) has emerged as one of the most extensively studied and utilized materials over the past two decades. This prominence is largely due to PLGA’s exceptional biocompatibility, adjustable degradation rates, and its well-documented history of safe use in clinical settings. The ability to fine-tune PLGA’s properties makes it particularly suitable for developing formulations that achieve specific, controlled drug release profiles.

To facilitate the rational design of PLGA-based drug delivery systems, this paper provides a comprehensive overview of the polymer’s key physicochemical characteristics, explores the various preparation methods used to fabricate PLGA carriers, and examines the mechanisms by which drugs are released from these systems. The discussion is focused on aligning formulation strategies with desired pharmacokinetic outcomes, thereby enhancing the efficacy and predictability of sustained release therapies.