Product/Service

ADMET-PK and Bioanalytical Services

Source: SCYNEXIS, Inc.
The ADMET-PK Team at SCYNEXIS understands the challenges in optimizing the bioavailability of a molecule and is well-equipped to determine compound adsorption, distribution and metabolism with state-of-the-art instrumentation and techniques. They are fully-integrated in our efforts to provide fast and efficient medicinal chemistry decision support for rapid hit seeking, H2L, lead optimization and candidate selection. Lead optimization projects are guided by a portfolio of in vitro DMPK assays including plasma stability studies, cytochrome P450 inhibition assays and metabolite identification leading to in vivo animal studies to determine PK parameters. We offer fully-integrated contract research, discovery and development services including Drug Discovery, ADMET-PK, Bioanalysis and Process Chemistry & GMP API manufacturing.

Success with SCYNEXIS
Our team works in state-of-the-art facilities with access to a comprehensive suite of high-end biological assays and bioanalytical instrumentation. We have successfully developed and delivered numerous assays to our clients' drug discovery and development programs including:

  • CNS/brain tissue exposure for Stage II Human African Trypanosomiasis (HAT)
  • Ocular tissue distribution of novel drug candidates for dry eye indications
  • Prodrug and parent monitoring to improve bioavailability and release profiles

In Vitro ADMET Capabilities

  • Rodent & Large Animal PK
  • Allometry
  • Routes of Elimination
  • Tissue/CNS Distribution
  • PK-PD
  • Metabolite Profiling

Bioanalytical Capabilities

  • Method Development
  • Sample Preparation
  • Tissue Extractions
  • Microtiter and Online SPE
  • Metabolite ID
  • Liquid Handlers
  • PK Screening
  • Tandem-MS (MRM and SRM)
  • Triple-Quadrupole MS
  • HTS Platforms (Beckman, Tecan, LEAP)
  • Prodrug Studies
  • PD Studies

Click Here To Download:
•Brochure: ADMET-PK And Bioanalytical Services
•Brochure: SCYNEXIS Overview
•SCYNEXIS Capabilities Overview

The bioavailability of any molecule depends on its absorption, metabolism and distribution in humans. To support both lead optimization and candidate selection, SCYNEXIS provides rapid generation of reliable ADMET and pharmacokinetic (PK) data on compounds in discovery through NDA filing. SCYNEXIS rapidly screens for properties such as metabolic stability and cytotoxicity to prioritize and differentiate lead series based on those key ADMET parameters.

To support both lead optimization and candidate selection, SCYNEXIS provides rapid generation of reliable ADMET and pharmacokinetic (PK) data for compounds in discovery through pre-IND filing. SCYNEXIS rapidly screens for properties such as metabolic stability, permeability and cytotoxicity to prioritize and differentiate lead series based on those key parameters.

SCYNEXIS ADMET-PK & Bioanalytical Services: Fully-integrated Biology Support

Our ADMET-PK team is integral to the SCYNEXIS drug discovery and development process. We routinely develop rigorous biological screening assays to support all phases of drug discovery. We have extensive experience handling cells, tissues and whole organisms such as whole organisms such as c.elegans, drosophila and trypanosomes. Our extensive use of high-throughput screening (HTS) platforms and automation enables our team to generate data on thousands of samples per week. Whether we are identifying hits, accelerating hits to leads or supporting lead optimization programs, SCYNEXIS believes that utilizing our fully-integrated biology team greatly enhances both the speed and efficiency of validating drug targets.

SCYNEXIS ADMET-PK & Bioanalytical Services: Bioanalytical Capabilities

Our bioanalytical team develops methods for preclinical and clinical sample analyses. SCYNEXIS can fully develop new methods and transfer existing methods for quantitative analysis of both APIs and metabolites. In support of preclinical and clinical development, SCYNEXIS performs analyses of compounds in various matrices and tissues across all species. We can process and analyze thousands of biological samples per week; the capability is supported with highly-experienced personnel, state-of-the-art facilities and automated LC-MS/MS instrumentation.

SCYNEXIS can customize protocols and reports based on therapeutic areas and customer's specifications. On average, the team has over 15 years of experience taking compounds from concept to clinic.

About SCYNEXIS:

SCYNEXIS is a premier drug discovery and development company offering fully-integrated contract research and manufacturing services including Medicinal Chemistry & Drug Discovery, In Vitro Pharmacology, ADMET-PK/Bioanalytical, Process Chemistry & cGMP API supply. SCYNEXIS is both FDA and DEA registered and headquartered in Research Triangle Park, NC – www.scynexis.com.

Click Here To Download:
•Brochure: ADMET-PK And Bioanalytical Services
•Brochure: SCYNEXIS Overview
•SCYNEXIS Capabilities Overview