Insights On Drug Development

  1. Unravelling Immunological Depths: Exploring Oxazolone-Induced Delayed-Type Hypersensitivity Model 3/28/2025

    Validating the oxazolone-induced DTH mouse model offers a critical platform for advancing the evaluation of therapeutic candidates for chronic inflammatory diseases, including atopic dermatitis.

  2. Enhancing mAb Processing With Protein A Membrane Chromatography For FIH Molecules 3/28/2025

    Our findings highlight this technology's potential in clinical development, providing greater flexibility, a smaller manufacturing footprint, and a more efficient purification process.

  3. Rapid And Simple Aggregate Removal Of mAbs Using Competitive Binding On CEX 3/28/2025

    To ensure the safety, efficacy, and stability of monoclonal antibody therapies, it is crucial to understand the factors driving aggregation and implement effective strategies to mitigate its impact.

  4. Therapeutic Effects Of An ALK5 Inhibitor In Preclinical Fibrosis Models 3/28/2025

    Our preclinical studies evaluating ALK5 inhibition in various mouse models of fibrosis have demonstrated differing degrees of therapeutic benefit, suggesting the potential for selective targeting.

  5. Comparing Immunotherapy, Standard Treatment, And Therapy On MC38 Colon Cancer 3/28/2025

    Our findings highlight the potential of combining irinotecan with immune checkpoint inhibitors in MC38 tumor models, demonstrating a promising approach for future research and therapeutic strategies.

  6. Reliable And Reproducible Preclinical Rodent Models Of MASH 3/28/2025

    Our preclinical studies highlight Elafibranor's potential in treating MASH and its progression to hepatocellular carcinoma, warranting further development.

  7. Optimizing Upstream Process Development To Increase mAb Titers 3/28/2025

    Uncover how we were able to help a client develop an efficient upstream process for a novel monoclonal antibody (mAb), resulting in a more than 100% increase in titers.

  8. Tag-Free Expression, in vivo Maturation, And Protein Purification 3/28/2025

    Optimizing recombinant expression and scalable purification strategies can help accelerate the production of challenging proteins, enabling successful program initiation and advancing pipelines.

  9. Introducing SUPR 3/28/2025

    Validating the performance of Getinge 50L and 250L single-use bioreactors alongside smaller-scale systems can optimize production processes and ensure scalability for CHO cell cultivation.

  10. A Translational Mouse Model For Non-Genetic Heterotopic Ossification 3/28/2025

    Reproducing the thermal lesion/tenotomy-induced mouse model can help overcome the challenge of unpredictable heterotopic ossification localization and enable the development of targeted interventions.