By David K. Lyon, Ph.D., Senior Fellow, Research
The increasing prevalence in pharmaceutical pipelines of active compounds with low solubility has led to the proliferation of approaches to increase oral drug absorption and bioavailability. Selection of the proper technology can make the difference between development success or failure.
Careful selection of the right technology to enhance bioavailability and oral drug absorption is essential in development programs from initial preclinical phases to commercialization. A science-based technology selection process is presented, based on a series of inputs including the target product profile, drug properties, extensive past project experiences, technology maps, and absorption modeling.