Scale-Up And Tech Transfer Of A Customer Cell Culture Process From 1000 L To 2 X 2000 L Across Two Sites

Scaling a bioprocess across equipment, manufacturing volumes and sites requires more than applying a single engineering parameter. Explore a real-world project that progressed from 1,000 L clinical manufacturing to 3,000 L stainless-steel production, followed by transfer to a second site using two 2,000 L bioreactors for commercial manufacturing.

See how tip speed and power input were applied during different stages of scale-up and tech transfer, and examine their impact on process performance. Key results include viability, viable cell concentration, product titer and product quality across scales and sites. The video also illustrates how process modifications driven by environmental health and safety requirements can affect product concentration without compromising overall manufacturing objectives.

Gain practical insight into managing scale-up and site transfer while maintaining comparable cell culture performance and product quality. Watch the webinar to explore the data behind this successful transfer.