Power Your Bioconjugation

Every step up in scale gives conjugate quality another chance to drift. Changes in process conditions, technology transfer, and site-to-site handoffs can all introduce variability, and the effects show up in the molecule. The infographic treats bioconjugation as more than chemistry, starting with the antibody itself and its influence on conjugation performance, purity, and program economics.

It includes chromatographic comparisons of DAR distribution and SE-HPLC purity across lab and pilot scales, including a CFD-guided mixing strategy and targeted optimization that addressed quality changes seen during scale-up. It also describes a standalone HPAPI facility supporting manufacturing from 20 L to 500 L in single-use and stainless-steel systems.

Review the scale-up data to see how the approach is built around the molecule.