mRNA Research Services To Accelerate Your Project

By Ilaria Pettinati, Ph.D., Group Lead Process Development - mRNA, and Alexander Schwenger, Ph.D., Head of Process Development - LNP

Decisions made during mRNA research and discovery can influence the direction, cost, and complexity of downstream development. In this Q&A, Lonza specialists discuss how in-silico codon optimization, small-scale construct testing, and lipid nanoparticle (LNP) encapsulation can be combined into a development pathway for teams that have already identified their target protein and tissue. The discussion explains how these activities fit together, where research-stage support concludes, and how services can be tailored to the needs and goals of individual projects.

The interview also addresses why LNP encapsulation is offered alongside mRNA development and explores a key consideration for research teams: whether encoding a protein as mRNA can be less costly than manufacturing the protein itself. Additional topics include the advantages of accessing external expertise for smaller biotechnology companies that may not have an established chemistry, manufacturing, and controls (CMC) team, as well as the types of nucleic acids that can be encapsulated. 

Read the full interview for the specialists’ answers and insights into how an integrated research approach can support progress toward in vivo evaluation.