Modified Release Tablets: Strategies For Optimising Drug Delivery

Modified release (MR) tablets play a vital role in modern pharmaceutical development by offering controlled and consistent drug delivery throughout the gastrointestinal tract. Unlike immediate‑release tablets, MR formulations maintain therapeutic drug levels for longer periods, helping minimise peaks and troughs that can cause side effects or reduce effectiveness. This approach also supports improved patient adherence by reducing the frequency of dosing, which is especially beneficial for chronic conditions such as hypertension, diabetes, and pain management.

A range of formulation strategies—including matrix systems, specialised coatings, osmotic technologies, and multi‑particulate approaches—enable tailored release profiles based on the drug’s characteristics and therapeutic goals. Successful MR development requires careful consideration of API solubility, permeability, half‑life, dose size, stability, and absorption window, ensuring the drug is released at the right time and place. With advancing technologies and expert formulation design, MR tablets provide a powerful pathway to improved treatment outcomes and a better overall patient experience.