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Medicinal & Synthetic Chemistry

Source: LAXAI
LAXAI - Synthetic Chemistry A

Explore the comprehensive support and expertise available for your drug discovery process.

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Our team consists of experienced professional chemists (Ph.D. and Masters) who have been trained at leading big pharma companies and universities in India, the US, and EU. Project-specific teams are organized upon the client’s request and are always led by a dedicated principal scientist and guided by experienced scientific management at LAXAI. Our highly skilled medicinal chemistry team has expertise and in-depth knowledge in preclinical drug discovery and is well-equipped to deliver on our clients’ expectations. The team has hands-on experience working on projects in various therapeutic areas, including oncology, central nervous system, inflammation, metabolic disorders, and anti-infective.

Medicinal chemistry support: We provide medicinal chemistry support for drug discovery and development, including library synthesis, parallel synthesis, reference compound synthesis, pro-drug synthesis, salt selection studies, and preclinical scale-up under GMP and non-GMP protocols.

Synthetic chemistry:

  • Multi-step synthesis and characterisation of target molecules.
  • Synthesis of Reference compounds and Metabolites
  • Custom synthesis of macrocyclics, reference standards & Impurity synthesis
  • Library design for Macrocyclic, Kinases, Proteases, Linkers of bioconjugation (anti-body, peptide drug-conjugates), heterocyclic based boronic acid, boronic esters, Carbohydrates, Peptides (10-12 amino acid side chains).
  • Key intermediates synthesis of quantity from milligram to multi-kilogram scale.
  • Synthesis of Lipids, PROTAC compounds, Nucleosides, and Nucleotides.
  • Expertise in Photochemical and electrochemical reactions.

We have the capability to synthesize compounds in the smallest quantity of a milligram to multi-kilogram quantities in a cost-efficient manner and deliver them within the given time frame. We provide our clients with Certificates of Analysis (COA), including analytical test reports and a concise final report in the desired format.

Infrastructure and Instrumentation:

  • Electronic laboratory notebooks (CDD Vault)
  • Cheminformatics software (ChemOffice, CS Chemdraw)
  • Scifinder Access and Reaxys Access
  • SharePoint Access
  • Teledyne-ISCO CombiFlash ® RF:Automated chromatography purification instrument. Equipped with UV and ELSD detectors.
  • Biotage CombiFlash ® RF:Automated chromatography purification instrument. Equipped with UV and ELSD detectors.
  • Grace Reveleris CombiFlash, Automated chromatography purification instrument. Equipped with UV and ELSD detectors
  • C-18 CombiFlash Columns (4g, 12g and 40g)
  • Rota-Evaporators
  • Diaphragm high vacuum pumps
  • High Vaccum pumps
  • CEM Discover ® Microwave Reactor
  • Radleys Parallel Synthesizer
  • Magnetic Stirrer-Oil bath Heating
  • Regular Magnetic Stirrer
  • Ceramic Hotplate Magnetic Stirrer
  • Advanced Fume Hoods (Argon, Nitrogen, and Water circulation)
  • Manifold system set up in every Fume Hoods
  • Air Flow Meter in the Hood
  • TLC UV Cabinet
  • Assorted Steel Bomb for high pressure reactions
  • Assorted Hydrogenation Reactors
  • Assorted overhead stirrers
  • Assorted Heating Mantles
  • THF Distillation Assembly
  • Analytical Balance Digital Precision Scale (mg scale)
  • Photochemical/ElectraSyn Set up

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