Ionizable Lipids To Optimize RNA-LNP Delivery

Lipid nanoparticles (LNPs) have revolutionized the field of intracellular drug delivery, providing targeted, efficient, and safe delivery mechanisms across a wide range of therapeutic applications. These applications include RNA vaccines, cell therapies, protein replacement, and gene editing. At the core of these advanced delivery systems are ionizable lipids, which serve as the key excipient. Ionizable lipids play a crucial role in protecting nucleic acids and facilitating their transport into cells. This video introduces the critical role of ionizable lipids in optimizing RNA-LNP delivery and highlights their significant impact on delivery potency, biodistribution, and pharmacokinetics.

Watch to learn how a well-characterized ionizable lipid portfolio enables the rational design of formulations that are scalable, reproducible, and maximize therapeutic performance. Whether you are advancing RNA-based therapeutics or exploring next-generation nanomedicine, understanding the properties of ionizable lipids is crucial to unlocking the full potential of LNP delivery.