Excellos360: Consolidating Clinical Correlates To Produce Predictive Outcomes Of Cellular Starting Material

By T. Cabreros, A. Price, C. Monckton, Ph.D., Z. Yang, Ph.D., R. Tressler, Ph.D.

Numerous studies have identified specific cellular characteristics that are strongly associated with functional performance. These include correlations between metabolic activity and proliferative capacity, the relationship between T cell polyfunctionality and therapeutic efficacy, as well as links between stemness and long-term persistence. Importantly, these individual traits have each demonstrated predictive value in relation to clinical outcomes.

Building on this foundational understanding, the Excellos360 platform was developed to systematically capture a wide range of biologically relevant variables — including, but not limited to, these key markers. Beyond simple data collection, the platform integrates these diverse attributes into a unified, multiparametric score. This condensed metric preserves the predictive power of traditional T cell assays while offering a scalable and efficient prescreening tool. As such, Excellos360 serves as a strategic approach to evaluate and generalize the therapeutic potential of cellular starting material early in the manufacturing process.