Dry Granulation In Solid Oral Formulation: Advantages Of Spray-Dried Mannitol In Roll Compaction

Pharmaceutical excipients play a crucial role in the formulation of solid dosage forms, often serving as fillers and binders. These substances are added to increase the volume of the formulation and enhance its mechanical properties, such as flowability and compressibility. Improved flowability ensures that the mixture can move smoothly through manufacturing equipment, while enhanced compressibility allows the formulation to be compacted into tablets or other solid forms with ease. In recent years, mannitol has emerged as a highly favored excipient in the formulation of solid dosage forms, thanks to its advantageous physicochemical properties. Mannitol is chemically inert, which means it does not react with other substances in the formulation, ensuring stability and efficacy. Its excellent compactibility allows for the creation of robust tablets that maintain their integrity during handling and storage.

Explore how these attributes enhance patient compliance, especially among populations such as children and the elderly who may have difficulty swallowing traditional tablets.