Drug Discovery Beyond Rule Of Five: ECCS Class 3 And 4 Strategies

Designing and advancing beyond‑rule‑of‑five candidates often requires navigating challenges that standard drug‑like molecules don’t pose. This webinar breaks down practical strategies for improving permeability, tuning metabolic stability, and enhancing cellular uptake, capabilities that are especially important when working with class 3 and class 4 ECCS compounds. Explore how modified in vitro systems and thoughtful physicochemical design can sharpen decision‑making early in discovery, reducing missteps in a notoriously difficult chemical space.

See how innovative medicinal chemistry approaches and emerging algorithms can help extend developability for large or highly polar scaffolds. For teams tackling complex modalities or struggling with high attrition, gain actionable guidance that can strengthen early‑stage program outcomes.