Cytiva And Asimov Collaborate On Next Generation Cell Line Design And Process Development

Biomanufacturers producing protein biologics including complex modalities, will have access to a full suite of custom cell line development and cell culture services to accelerate and optimize biologics production.

Asimov, the synthetic biology company advancing the design and manufacture of therapeutics, is collaborating with Cytiva, a global life sciences leader, to provide customers with an integrated offering for optimized biologics production. The new offering will provide seamless access to Asimov’s CHO Edge cell line development platform, Cytiva's HyClone media and feed solutions, and Cytiva’s Fast Trak process development services. Together, these services and technologies enable the expression and development of protein biologics, including complex modalities, that hold the potential to significantly impact human health.

Alec Nielsen, co-founder and CEO of Asimov, says: “Central to this collaboration is the extensive optimization of our CHO Edge System in Cytiva’s HyClone media and feed, enabling high titer across biologic formats. By integrating a robust cell line development capability into Cytiva’s established biomanufacturing technologies, we can enhance customers’ production efficiency and accelerate their development timelines for critical therapeutics.”

Ludovic Brellier, President, Hardware Solutions, Cytiva says: “We’re two innovative players coming together to provide the technologies and services our customers need to accelerate the development of advanced therapeutics. By combining Asimov’s integrated suite of cells, genetic tools, AI models, and software with our extensive process development services, customers will have a cohesive path from development to commercialization.”

Cell line development technology has improved substantially over the years, but the majority of complex biologics are still produced using relatively low-titer cell lines. Asimov’s CHO Edge System, which enables molecule-specific expression optimization, significantly reduces the risk of low titer cell lines and enables customers to routinely achieve 7-11 g/L clones across biologic modalities. The system leverages a GS knock-out CHO host, a hyperactive transposase, a library of genetic elements, and advanced computational tools to design and optimize the vector. When paired with Cytiva’s Fast Trak process development services and HyClone media and feed, the new offering provides customers with a full suite of solutions from cell line development; cell culture media optimization; analytical and stability testing; and scaling to GMP production.

Learn more about Cytiva’s Fast Trak process development services (https://www.cytivalifesciences.com/en/us/solutions/bioprocessing/services/process-development?srsltid=AfmBOooSD25mQpw_ZYWfckk8raF3xpAch-W1S7aj6DvIafDL28s5I8wH) and HyClone media and feed (https://www.cytivalifesciences.com/en/us/shop/cell-culture-and-fermentation/media-and-feeds).

Here’s (https://www.asimov.com/cho-edge-expression-system) more information on Asimov’s CHO Edge cell line development platform.

About Asimov
Asimov’s mission is to advance humanity’s ability to design living systems, enabling biotechnologies with outsized societal benefit. The company is developing a synthetic biology platform – from cells to software – to design and manufacture next-generation therapeutics, including biologics, cell/gene therapies, and RNA through a combination of products, services, and collaborations.

Founded by bioengineers from MIT and Boston University and headquartered in Boston, the company has raised over $200M from top institutional investors including Andreessen Horowitz, CPP Investments, Horizons Ventures, and Fidelity Management & Research Company. For more information, visit www.asimov.com.

About Cytiva
At Cytiva, our mission is to advance and accelerate the development of therapeutics. With 15 000 associates in more than 40 countries, we’re driven to use our expertise and talent to achieve better flexibility, capacity, and efficiency for our customers. Our broad and deep portfolio of tools and technologies, global scale, and best-in-class service provides critical support from discovery to delivery, for customers spanning researchers, emerging biotech, large-scale biopharma and contract manufacturers. For more information, visit cytiva.com.