Bioreactor Modeling To De-risk Scale-Up And Scale-Down Across The Product Lifecycle

Bioreactor modeling can reduce uncertainty during process scaling and transfer by helping teams understand how operating conditions translate between scales. In early development, modeling can support process transfer and scale-up. During later phases, it can help establish representative downscale models for process characterization, troubleshooting and commercial manufacturing transfers across scales or sites.

Explore a practical example involving a GMP process operating in a 1,000 L single-use bioreactor. By comparing a traditional scale-down approach based on power input with a model incorporating shear stress, researchers achieved a downscale model that more closely represented manufacturing-scale conditions. The results demonstrate why a scale-down model does not need to replicate every parameter perfectly to provide meaningful improvement.

Learn how bioreactor modeling can strengthen scale-down strategies and support more informed decisions throughout a process lifecycle.