Almac Pharmaceutical Development: Solid Oral Dose Formulation And Manufacturing Services

Solid oral dose programs rarely stay simple as they advance. Batch sizes climb from grams to 2,500 kilograms, potent compounds demand containment, and the handoff from non-GMP development to GMP manufacture can slow a program down.

This brochure follows one CDMO's route from early formulation through registration batches to commercial supply. Formulation types run from micro-dosed capsules to modified release and fixed dose combinations. Containment is built around compounds with occupational exposure limits as low as 0.05 μg/m3 over eight hours. A post-commercialisation example covers paediatric mini-tablets filled into stickpacks.

Read on to see how the containment approach and the mini-tablet work play out in practice.