Advancing Aseptic Filling: Evaluating The Revolutionary SA25 Workcell

Fully robotic aseptic filling systems are a revolutionary technology for drug product manufacturing as they eliminate the root cause of problems in existing fill line technology: human intervention. The SA25 Workcell, designed and built by Vanrx (now Cytiva), stands out as a major step forward in manufacturing technology and is capable of precisely filling drug products into vials, syringes, and cartridges — all without human intervention.

The SA25 Workcell's groundbreaking design goal dictated that all filling operations would occur entirely within an isolator under a Grade A environment, without glove ports. The use of semiconductor-grade robotics and control systems, tray handling of Ready-to-Use (RTU) components instead of individual containers, and the utilization of nested press-fit vial closures and stoppers combine to achieve the key benefits of the equipment.

Singota Solutions, the first CDMO in North America to adopt the SA25, reviews the performance of the SA25 across presentations spanning vials, syringes and cartridges of various sizes and processing a wide range of small and large molecules. Examine how leveraging a fully robotic aseptic filling system enables versatility, high yields, and low losses, as well as precise and repeatable fill parameters batch to batch.