Posters
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ATLAS: A High-Throughput Screening Platform For Optimizing AAV Production
2/11/2025
To overcome manufacturing bottlenecks and reduce the high cost of gene therapies, our ATLAS platform has identified novel factors that boost rAAV9 production over 30-fold.
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Development Of A Next-Generation AAV Helper Plasmid With Improved AAV9 Productivity
2/11/2025
Enhancing AAV production efficiency is critical for expanding gene therapy applications — this optimized helper construct significantly boosts yield and potency.
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Comparing Synthesis Processes To Establish rAAV Batch Quality
2/5/2025
In this study, we present a comprehensive analysis of various published and newly developed dsDNA conversion processes that were tested using the same sequencing chemistry.
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Targeted CRISPR/Cas9 Screen Identifies Superior HEK293 Cell Lines For AAV9 Production
2/5/2025
In this study, we developed a proprietary clonal suspension-adapted HEK293 cell line (AC001.230) through clonal isolation and high-throughput screening, resulting in improved productivity for 7 out of 10 AAV serotypes compared to 293F cells.
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High-Throughput Screen Finds Targets To Boost AAV9 Production In HEK293 Cells
2/5/2025
Take a look at the potential of this small molecule screening to enhance AAV9 production and improve gene therapy manufacturing efficiency by leveraging novel compounds.
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Plasmid Impurity Sizing Of nptII In rAAV By ddPCR
2/5/2025
Explore our novel ddPCR method for assessing plasmid-derived antibiotic resistance gene impurities in rAAV products to enhance regulatory compliance and ensure the safety and quality of gene therapy vectors.
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Method Qualification Of Mass Photometry For The Determination Of Full-To-Empty Capsid Ratio For rAAVs Using The Refeyn System
2/5/2025
Leverage mass photometry to quickly and accurately monitor the full-to-empty ratio of rAAV samples, ensuring consistent product quality and enhanced safety and efficacy in gene therapy applications.
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Design Of Experiment (DoE) Based High Throughput Process Optimization For rAAV Manufacturing Development
2/5/2025
This study presents the results of a Design of Experiment (DoE) approach to assess how these process parameters impact rAAV yield and quality.
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Developing A Scalable Full Empty Separation Step For An AAV Capsid By Anion Exchange Chromatography In Step Gradient Elution Mode
2/5/2025
Explore how our scalable anion exchange chromatography method can enhance full capsid enrichment and improve the quality of your rAAV manufacturing process.
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Quality Over Quantity: Where Is The Trade Off?
2/5/2025
Our study aims to compare two widely used transfection reagents to our standard process, evaluating their impact on final product quantity and quality as part of our ongoing platform innovation efforts.