Spray Dry Biologics For Oral Dosage Forms

By Dr. Richard Johnson, Chief Scientific Officer

Spray drying is gaining attention as a powerful technique for enabling oral delivery of biologics, a format traditionally limited by the instability of large, complex molecules in the gastrointestinal environment. While oral solid dosage forms remain the most common and convenient treatment option, biologics have historically required injection due to their sensitivity to degradation. Spray drying addresses this challenge by transforming biologics into stable dry powders, preserving their structure while protecting them from environmental stress.This approach allows incorporation into tablets or capsules

designed for targeted release within specific regions of the digestive system. By optimizing excipients and particle properties, spray drying enhances stability, bioavailability, and processability, making downstream manufacturing more efficient. The method also supports advanced formulation strategies such as controlled or site-specific drug release. As research advances, spray drying is emerging as a key technology for expanding the use of biologics beyond injectable formats into more patient-friendly oral therapies.