Spray Dried Dispersions: Performance, Manufacturability, Stability

The current wave of new molecular entities (NMEs) increasingly demands sophisticated bioavailability enhancement strategies due to their complex and challenging physicochemical profiles. A growing number of these compounds not only exhibit poor aqueous solubility but also limited solubility in conventional volatile organic solvents used in spray drying—posing a significant hurdle for formulation scientists. Compounding this challenge, these molecules often demonstrate a strong tendency to rapidly crystallize after being converted to an amorphous form, undermining the stability and effectiveness of the formulation.

This presentation will explore advanced approaches to designing robust amorphous formulations and optimizing spray drying processes tailored specifically to these difficult-to-formulate compounds, with a focus on overcoming solubility limitations and crystallization tendencies.