Solving Bispecific Antibody Heavy-Light Chain Mispairing With bYlok® Technology

Lonza’s bYlok® bispecific pairing technology is an innovative solution that drives correct heavy-light chain pairing rates in IgG-like bispecifics to >95%. This improves yields of the correct species and streamlines downstream processing, without affecting key performance attributes of the molecule.

In this talk, we present the latest case studies of bYlok® engineered bispecifics and explore how bYlok® stacks up against other established pairing solutions. We’ll also show how elements of Lonza’s GS® toolbox can be used to increase yields of such engineered molecules.