Rethinking Ion Exchange Chromatography Modeling Using The Colloidal Particle Adsorption (CPA) Model

In the early days of modeling, mechanistic models for ion exchange chromatography were mostly based on stoichiometric equations. The 2021 release of the GoSilico™ Chromatography Modeling Software has introduced a new adsorption isotherm class that is based on a colloidal description of proteins, the colloidal particle adsorption model (CPA). In comparison to the standard steric mass adsorption (SMA) model, the new colloidal model achieves increased accuracy at high column loading.

Learn about the CPA model in greater detail and how it achieves increased accuracy at high column loading in IEX modeling.