Q&A Bilayer Tablet Manufacturing

Source: AbbVie

By Dr. Éanna Ó Maitiú, Technical Operations Manager, at AbbVie Cork, Ireland

A bilayer tablet involves the compression of two formulations into a single solid oral tablet, while maintaining a physical separation of the formulations by layering one on top of the other. Bilayer is considerably more convenient for patients due to receive multiple medications or longer-lasting profiles in a single dosage form and has the added benefit of improved patient compliance.

This Q&A explores the manufacturing challenges, how to overcome them and considerations when selecting a CDMO for the manufacturing process.

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